The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity that leads ultimately to death. HIV infection in humans is caused by ...

Disease progression in untreated human immunodeficiency virus (HIV) infection can take many years, and it was originally hypothesized to be a consequence of slow, viral-mediated CD4 + T-cell destruction. However, massive CD4 + memory T-cell destruction is now known to occur quite early in infection, almost always without overt immunodeficiency.

2023年8月1日 · Human immunodeficiency virus (HIV) infection may cause death by damaging some of the patient’s vital organs through weakening the body’s immune system, including CD 4 + T cells. In the meantime, mathematical models can be useful in dealing with this deadly virus by providing effective strategies based on the examination of different ...

2013年6月4日 · In an activated state, CD4 + T cells residing in lymphoid organs are a major reservoir of ongoing HIV-1 replication in infected individuals. In contrast, resting CD4 + T cells are highly...

2023年5月9日 · Here, we used a primary cell-based in vitro latency model and demonstrated that co-culture of autologous activated CD8 + T cells with HIV-infected memory CD4 + T cells promoted specific changes in metabolic and/or signaling pathways resulting in increased CD4 + T cell survival, quiescence, and stemness.

2019年7月15日 · Analysis of the whole-genome transcriptional activity of HIV-specific CD4 + T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional...

Latent infection of CD4 + T cells is the main barrier to eradicating HIV-1 infection from infected patients. The cellular and molecular mechanisms involved in the establishment and maintenance of latent infection are directly linked to the transcriptional program of the different CD4 + T cell subsets targeted by the virus.

Two laboratory tests, CD4 + T-cell count and plasma viral load (PVL) measurements are two approaches employed; the PVL measures viral replication, while the CD4 + T-cell count correlates with the functional implications of the immune system in the HIV-infected individual.

Disease progression in untreated human immunodeficiency virus (HIV) infection can take many years, and it was originally hypothesized to be a consequence of slow, viral-mediated CD4 (+) T-cell destruction. However, massive CD4 (+) memory T-cell destruction is now known to occur quite early in infection, almost always without overt immunodeficiency.

目的 研究艾滋病病毒 /艾滋病 (hiv/aids)患者cd+ 4 ,cd+ 8t淋巴细胞数与外周血各组份间白细胞(wbc),血小板 (plt),血红蛋白 (hgb),粒细胞百分数 (gr % ),淋巴细胞百分数 (ly % ),ly的相关性 ,为临床治疗提供参考依据.方法 hiv/aids患者抗凝外周血 5 13份 ,在 6小时之内检测其血细胞 ...