2020年3月17日 · CD103+ PDCs are critical to adaptive immunity against pulmonary infections. They not only excel in cross-priming CD8+ T cells to generate antigen-specific cytotoxic responses against viruses but...

它是机体功能最强的专职 抗原递呈细胞 (Antigen presenting cells, APC)，它能高效地摄取、加工处理和递呈抗原，未成熟DC具有较强的迁移能力，成熟DC能有效激活初始型 T细胞，处于启动、调控、并维持免疫应答的中心环节。 DC与肿瘤的发生、发展有着密切关系，大部分实体瘤内浸润的DC数量多则患者预后好。 有效的抗肿瘤免疫反应的核心是产生以CD8+ T细胞为主体的细胞免疫应答，这也是DC作为免疫治疗手段的基础。 美国 杜克大学 遗传和细胞治疗学中心的研究主任 …

Strategically positioned within the lamina propria, CD103 + DCs play an important role in maintaining intestinal immune homeostasis. These cells are required for the induction of tolerogenic immune responses and imprinting gut homing phenotypic changes on …

使用小鼠黑色素瘤模型，我们发现CD103 + 树突状细胞（DCs）是将完整抗原转运至淋巴结并引发肿瘤特异性CD8 + T细胞的唯一APC 。 CD103 + DCs被要求在阻断检查点配体PD-L1时增强抗肿瘤作用。 但是，PD-L1抑制仅导致部分反应。 全身性施用生长因子FLT3L，随后进行肿瘤内多聚I：C注射，扩大并激活CD103 + 肿瘤中的DC祖细胞增强了对BRAF和PD-L1阻滞的反应，并保护小鼠免受肿瘤攻击。 因此，肿瘤中活化的CD103 + DCs的缺乏限制了检查站封锁的效力，并 …

Intravenous CBD-CCL4 administration recruits CD103 + DCs and CD8 + T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. Thus, CBD-CCL4 holds clinical translational potential by enhancing efficacy of CPI immunotherapy.

2020年12月2日 · cDC1s express surface CD8α and CD103 (integrin αE) in lymphoid and non-lymphoid tissue, respectively. Both lymphoid and non-lymphoid tissue cDC1s share a very similar transcriptional profile and...

2016年4月19日 · Using mouse melanoma models, we found that CD103 + dendritic cells (DCs) were the only APCs transporting intact antigens to the lymph nodes and priming tumor-specific CD8 + T cells. CD103 + DCs were required to promote anti-tumoral effects upon blockade of the checkpoint ligand PD-L1; however, PD-L1 inhibition only led to partial responses.

2021年8月19日 · Human cDC1s and cDC2s are distinguished by their surface expression of CD141 and CD1c, respectively. Mouse cDC1s are recognized by the surface expression of XCR1, CLEC9A, and CD8α...

CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103(+) DCs display distinct functional activities. Migratory CD103(+) DCs derived from skin, lung, and intestine efficiently present exoge …

2025年4月4日 · In vitro studies identified distinct properties affected by IRF8 expression. A) Graphical illustration of the experimental setup for bone-marrow derived CD103 + DC cultivation. B) Dot plot of GO enrichment analyses with terms of interest for the transcriptional level of upregulated genes of Irf8-OE BMDCs versus control ones.