2023年5月31日 · cd69和cd103：一般认为cd103+ cd8+代表真正的trm原亚群特征。 人和小鼠肺trm均表达cd69。 部分表达cd103和/或cd49a，分别通过与细胞外基质中的上皮e-钙粘蛋白和胶原蛋白相互作用进一步支持其保留。 肺部trm特征之一还包括缺乏ly6c表达。 趋化因子：

2024年10月20日 · Accumulation of CD103+CD8+ resident memory T (TRM) cells in human lung tumors has been associated with a favorable prognosis. However, the contribution of TRM to anti-tumor immunity and to the response to immune checkpoint blockade has not been ...

2022年11月11日 · To address the plasticity of intestinal Trm subsets and their role in local and systemic immunity, we generated mice to fate map intestinal CD103 + Trm cells and track their location and function during secondary infection with Yersinia pseudotuberculosis.

2022年2月14日 · CD103 + CD8 + tissue-resident memory T (T RM) cells, associated with better overall survival among various malignancies, are thought to activate anti-tumour immune response and affect...

2024年12月18日 · CD8 + tissue-resident memory T (TRM) cells are strategically positioned to mediate effective anti-tumor responses. However, the characteristic surface molecules and functions of CD8 + TRM cells exhibit significant heterogeneity.

2023年4月16日 · 作者发现cd69+cd103-和cd69+cd103+ t细胞的转录组显著富含小鼠皮肤、肠道和肝脏病毒感染后cd8+ trm细胞的转录标记（图1k），以及从早期tnbc肿瘤中提取的cd8+ trm基因标记（图1l）。

2025年2月26日 · CD8 + TRM cells express specific surface receptors, such as CD103, CD69, and CD49a, that are mutually present or mutually exclusive for the identification, retention, and reactivation of CD8 + TRM cells [].These surface receptors were recognized as immunophenotypic markers of CD8 + TRM cells in HNSCC and associated cancer subtypes including OSCC utilizing multiplex immunohistochemistry (MxIHC ...

2022年3月6日 · trm的标志物为cd103，由itgae基因编码。 CD103+TRM在实体瘤的免疫监视以及限制肿瘤生长中起着重要作用。 研究表明，在接受标准治疗的癌症患者中，该类细胞的肿瘤浸润与更好的临床结果相关。

In this report, we show that human lung tumor CD8 + T RM cells are a homogeneous CD103 + CD49 + CD69 + population characterized by the expression of T-bet, phosphorylated (p)STAT-3, and Aiolos transcription factors, and that a subset of them produces IFN-γ …

2020年6月2日 · This study examines the expression patterns and functions of CD103 and CD49a with a specific focus on their impact on T cell motility during influenza virus infection. We show that the T RM cell surface phenotype develops by 2 wk postinfection, with the majority of the population expressing CD49a and a subset that is also positive for CD103.