Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (C luster of D ifferentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene. The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family.

The decoy receptor IL-1R2 (also known as CD121b) can suppress IL-1 maturation, sequester its active forms or hinder the signaling complex assembly. IL-1R2 is differentially expressed among numerous cell types and displays cis - and trans - modes of action.

CD121b is encoded by the Il1r2 gene and presents as a 68 kDa type I transmembrane glycoprotein. It is expressed on a variety of cell types including B cells, neutrophils, monocytes, and bone marrow progenitor cells. A soluble form of CD121b is produced by proteolysis especially after cellular activation.

CD121b is a 60 kDa cytokine receptor, which is a ligand for interleukin-1 (IL-1). There are two forms of the IL-1 receptors. The type I receptor is mainly involved in transmitting the inflammatory effects of IL-1 while type II receptor plays a role as a suppressor of IL-1 activity by competing for IL-1 binding.Additional information: Clone ...

分为两型：i型受体(cd121a)表达于t细胞和间质来源的细胞，与il-1r辅助蛋白组成高亲和力受体，介导信号转导；ii型受体(cd121b)表达于b细胞和髓单核细胞，为诱骗受体。

CD121b, also known as interleukin-1 receptor type II (IL-1RII), has a significant role in the inflammatory response. Interleukin-1 receptor type II acts as a decoy receptor to regulate prolonged persistence of IL-1 by binding to IL-1 and preventing the …

2024年7月30日 · The decoy receptor interleukin 1 receptor 2 (IL-1R2), also known as CD121b, has different forms: membrane-bound (mIL-1R2), soluble secreted (ssIL-1R2), shedded (shIL-1R2), intracellular domain (IL-1R2 ICD ).

CD121b / IL1R2 interleukin 1 receptor, type II. Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B.

IL-1R2 Protein, Cynomolgus (HEK293, Fc) 是一种重组食蟹猕猴 IL-1R2 蛋白，在 HEK293 细胞中表达，由 343 个氨基酸组成 (M1-E343)。 C 末端带有 hFc 标签。 IL-1R2 是 IL-1 信号通路的竞争性内源性抑制剂。 IL-1R2 作为诱饵受体与 IL-1R1 竞争 IL-1，与 IL-1 结合后也可与 IL-1RAP 形成复合体。 IL-1R2 与多种 IL-1 介导的炎性疾病有关。 IL-1R2 Protein, Rat (HEK293, His) 是一种重组大鼠 IL-1R2 蛋白，在 HEK293 细胞中表达，由 355 个氨基酸组成 (M1-E355)。 C 末端带 …

2015年10月20日 · An antigen occurring in two isoforms. Both represent the receptors for IL-1. The CD121a represents IL-1RI and is localised on T-lymphocytes, thymocytes, endothelial cells and fibroblasts. The CD121b represents IL-1RII and is localised on B-cells, macrophages and...