2018年1月25日 · We find that in vivo administration of an anti-CD122 mAb (CD122 blockade) restores immune tolerance in nonobese diabetic (NOD) mice via multiple mechanisms. First, …

2018年10月1日 · Here we demonstrate that costimulation-independent T cell alloreactivity relies on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. Combined …

CD122 is highly expressed on antigen-specific memory CD8 + T cells. High levels of CD122 expression distinguish memory CD8 + T cells and NK cells . Consistent with previous reports, …

CD8 + CD122 + T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve …

CD122 (IL-2/IL-15 receptor β chain)-deficient mice exhibit severe hyperimmunity with augmented granulopoiesis and suppressed erythropoiesis. Severe anemia progresses, and the mice die …

2024年10月15日 · Discover the critical role of CD122 in modulating T cell responses for immunotherapy. This in-depth exploration covers how antibodies like TM-β1 target CD122 to …

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2024年6月26日 · ADAM17 inhibition led to elevated CD122 expression and enhanced response to IL-2 and IL-15 stimulation in both mouse and human CD8 + T cells. Intriguingly, inhibition of …

2018年9月17日 · CD122 is highly expressed on antigen-specific memory CD8 + T cells. High levels of CD122 expression distinguish memory CD8 + T cells and NK cells . Consistent with …

2020年7月29日 · Here, we show that CD122-targetted IL-2 signals delivered systemically by S4B6 IL-2C, while increasing cellularity of secondary lymphoid organs including mesenteric …