
Interleukin-4 receptor - Wikipedia
The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor). [5]
白细胞介素4受体(IL-4R/IL-4Ra):细胞因子多功能靶点,哮喘、 …
2024年3月29日 · 白细胞介素-4受体(il-4r,又叫cd124;il4rα)是一种i型跨膜蛋白,属于白细胞介素家族成员之一。 IL4Rα链cDNA全长3.6 kb,含有一个编码825个氨基酸的开放阅读框架,根据推测其中包括信号序列(25个氨基酸),细胞外区(207个结合域氨基酸),跨膜区(24个氨基酸 ...
IL-4R alpha/CD124 (IL-4R alpha/CD124) | 重组蛋白 | MCE
IL-4R alpha/CD124, Rat 由 801 个氨基酸 (M1-S801) 组成,通过结合 IL-4,使 C- 端络氨酸残基发生磷酸化。IL-4R alpha/CD124, Rat 具有一个免疫受体酪氨酸基抑制剂基序 (ITIM) (698-703 a.a),通过磷酸化 ITIM,可结合部分磷酸酶的SH2结构域。
IL4R - 维基百科,自由的百科全书
白介素-4受体α亚基(Interleukin-4 receptor subunit alpha,缩写IL4R-α或IL4R)也称为分化簇124(CD124,cluster of differentiation 124)是一种细胞表面蛋白质,由人类基因 IL4R 编码 [5] ,与γ链(CD132)共同组成I型白介素-4受体(IL4R type I),或与白介素-13受体α1(CD213a1)组成II型 ...
CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™ | Miltenyi Biotec …
Clone REA235 recognizes the CD124 antigen, a 140 kDa transmembrane glycoprotein which is also known as interleukin-4 receptor subunit alpha (IL-4Rα). CD124 is expressed on both B and T lymphocytes, and on cells of several other hematopoietic lineages, including mast cell, macrophage, and undifferentiated hematopoietic cell lines.
Purified anti-mouse CD124 (IL-4Rα) Antibody - BioLegend
CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13.
CD124 Monoclonal Antibody (X2/45-12) (14-1249-82)
Invitrogen Anti-CD124 Monoclonal (X2/45-12), eBioscience™, Catalog # 14-1249-82. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Flow Cytometry (Flow) and Functional Assay (Functional) applications. This antibody reacts with Human samples. Supplied as 100 µg purified antibody (0.5 mg/mL).
BD Pharmingen™ Purified Rat Anti-Mouse CD124 - BD Biosciences
The mIL4R-M1 monoclonal antibody specifically binds to CD124 which is also known as the α subunit of the mouse Interleukin-4 Receptor (IL-4Rα). The mouse IL-4Rα is a 140 kDa transmembrane glycoprotein that is expressed by B and T lymphocytes and a variety of other hematopoietic and nonhematopoietic cells and cell lines.
BioXCell--InVivoSIM anti-human IL-4Rα (CD124) (Dupilumab …
2024年2月21日 · IL-4Rα也称为CD124,它与普通γ链(CD132)结合形成仅结合IL-4的1型IL-4R,或与IL-13Rα1结合形成可结合IL-4或IL-13的II型IL-4R。 IL-4Rα在各种细胞上表达,包括T辅助型2(Th2)细胞、肥大细胞、嗜碱性粒细胞、嗜酸性粒细胞、巨噬细胞、树突状细胞和内皮细胞。 IL-4Rα在这些不同细胞上的表达允许对IL-4和IL-13产生各种细胞反应,包括调节免疫细胞分化、活化、增殖和存活。 此外,IL-4和IL-13的信号传导通过IL-4Rα可以促进组织修复和重塑,并有 …
InVivoSIM anti-human IL-4Rα (CD124)的科研应用 - 脉脉
2024年12月17日 · IL-4Rα也称为CD124,与常见的γ链(CD132)结合形成仅结合IL-4的1型IL-4R,或与IL-13Rα1结合形成可结合IL-4或IL-13的II型IL-4R。 IL-4Rα在各种细胞类型上表达,包括T辅助2型(Th2)细胞、肥大细胞、嗜碱性粒细胞、嗜酸性粒细胞、巨噬细胞、树突状细胞和内皮细胞。 IL-4Rα在这些不同细胞类型上的表达允许对IL-4和IL-13产生各种细胞反应,包括调节免疫细胞分化、活化、增殖和存活。 此外,IL-4和IL-13通过IL-4Rα的信号传导可以促进组织修复和 …
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