CD135 is the receptor for the cytokine Flt3 ligand (FLT3L). It is expressed on the surface of many hematopoietic progenitor cells. Signalling of FLT3 is important for the normal development of haematopoietic stem cells and progenitor cells.

In this study, we determined the cell-surface expression of the FLT3 receptor (CD135) on the blast population and retrospectively analyzed whether expression was correlated with disease characteristics and clinical outcomes in pediatric patients with de novo AML.

The aim of this study was to evaluate the frequencies of CD135 and CD117 expressions in leukemic blast cells, the degree of CD135 and CD117 co-expression (CD135+CD117), and the association of that co-expression with the event-free survival (EFS) …

The FLT3 receptor (Fms-like tyrosine kinase 3), also known as FLK2 (fetal liver tyrosine kinase 2), STK-1 (stem cell tyrosine kinase 1) or CD135, is encoded by the FLT3 gene located on chromosome 13q12. 6–7 This gene consists of 24 exons and covers approximately 96 kb; the exact size is unknown because of the presence of a large intron (>50 ...

Fms-Like Tyrosine Kinase 3 (Flt3) also known CD135 is the receptor for Flt3-Ligand (Flt3L) that is critical for the development and differentiation of cDC and pDC subsets. cDC1s express higher levels of Flt3 mRNA and protein on the cell surface compared to cDC2 and pDC but all three subsets require Flt3L for their development and can be ...

CD135 Antigen In subject area: Medicine and Dentistry The Flt3 receptor is a single transmembrane protein and has an extracellular region composed of five immunoglobulin-like domains, a single transmembrane region, a juxtamembrane (JM) domain, a conserved tyrosine kinase domain spaced by a kinase insert region, and a C-terminal region.

2022年8月1日 · In the current study, we identified the CD135 + subset of monocytes as a novel class of APCs in mice. CD135 + monocytes were readily found in the bone marrow, spleen, and peripheral blood at steady state, and they expressed markers specific to DCs, including MHC class II and CD209a, along with markers for monocytes/macrophages.

CD135 is an important cell surface marker used to identify certain types of hematopoietic (blood) progenitors in the bone marrow. Specifically, multipotent progenitors (MPP) and common lymphoid progenitors (CLP) express high surface levels of CD135.

CD135 expression ≥ 25% was a predictor of FLT3-ITD mutation (P = .03). CD135 overexpression was a negative predictor of complete remission and of postinduction minimal residual disease at days 14 and 28 (P < .001).

2019年9月1日 · The aim of this study was to evaluate the CD135 and CD117 expression, co-expression of CD135 and CD117 (CD135+CD117), and the association of that co-expression with Event Free Survival (DFS) and Overall Survival (OS) rates.