2024年12月24日 · CD151 (CD151 Molecule (Raph Blood Group)) is a Protein Coding gene. Diseases associated with CD151 include Epidermolysis Bullosa Simplex 7, With Nephropathy And Deafness and Raph Blood Group System. Among its related pathways are Cell junction organization and Collagen chain trimerization.

CD151 molecule (Raph blood group), also known as CD151 (C luster of D ifferentiation 151), is a human gene. [5] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

2013年11月18日 · CD151 regulates post-adhesion events, that is, cell spreading, migration and invasion including subsequent intravasation and formation of metastasis. Present on both neoplastic and endothelial...

CD151 regulates α6β4 distribution by enhancing protein kinase Cα (PKCα)—α6β4 integrin association and PKC-dependent β4 S1424 phosphorylation. CD151 in complex with PKCα enhances invasive behavior by phoshorylating β4 integrin, thus affects subcellular localization and epithelial disruption.

2023年5月1日 · CD151 is a transmembrane protein implicated in tumor progression and has been shown to regulate various cellular and molecular mechanisms contributing to malignancy. More recently, the role of CD151 in the tumor immune microenvironment (TIME) has gained attention as a potential target for cancer therapy.

CD151 regulates post-adhesion events, that is, cell spreading, migration and invasion including subsequent intravasation and formation of metastasis. Present on both neoplastic and endothelial cells, CD151 is engaged in promotion of tumour neovascularization.

CD151 is a transmembrane protein implicated in tumor progression and has been shown to regulate various cellular and molecular mechanisms contributing to malignancy. More recently, the role of CD151 in the tumor immune microenvironment (TIME) has gained attention as a potential target for cancer the …

CD151是四跨膜蛋白超家族(transmembrane 4 superfamily，TM4SF)中的一个成员，它能将整合素接收到的生物信号转导到细胞内的其他关键蛋白质(如激酶)，参与细胞的黏附、迁移、形成半桥粒结构等多种病理生理过程，在肿瘤细胞的迁移、侵袭和转移中起重要作用，其过 ...

Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathologic angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. Here we report ...

2019年2月18日 · CD151, a 30 kD tetraspanin protein family member, is widely expressed in many tissues and cancer cell types [1–3]. CD151 expression is increased in breast, prostate, lung, colon, skin, and other cancers, and elevated CD151 expression correlates with advanced stage and poor prognosis in many of these human cancers [3–5].