2015年11月4日 · We determinerd that CD200/CD200R interactions upregulate peptidylprolyl isomerase A (PPIA) inhibiting the production of TNF-α and IL-2, induces the formation of myeloid derived suppressor cells (MDSC) and tolergenic antigen presenting cells. We developed a competitive inhibitor of CD200 capable of overcoming CD200 induced suppression.

The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli.

2021年10月12日 · CD200 receptor 1 (CD200R) is an inhibitory immunoreceptor that suppresses Toll-like receptor (TLR)–induced cytokine production through the adaptor protein Dok2 and the GTPase activating protein (GAP) p120-RasGAP, which can be cleaved during mild cellular stress.

2020年1月3日 · We determined that targeting the CD200 activation receptors (CD200AR) of the CD200 checkpoint with a peptide inhibitor (CD200AR-L) overcomes tumor-induced immunosuppression. We have shown the clinical efficacy of the CD200AR-L in a trial in companion dogs with spontaneous high-grade glioma.

2021年2月5日 · Interestingly, while expression of CD200 rapidly decreases using treatment with the MEK inhibitor (UO126), resistance develops to this treatment, consistent with the idea of alternate (MEK-independent) pathways of regulation of CD200 expression (transcriptional and/or translational) in human cancer cells.

2014年12月16日 · CD200-derived peptides were used as competitive inhibitors in a mouse model of glioblastoma immunotherapy. CD200 mRNA levels were measured in human brain tumors, with different expression levels being noted among the sub groups of glioblastoma, medulloblastoma and ependymoma.

2023年11月1日 · One model captures the tumor inhibition by CD200-CD200R in melanoma by including the anti-cancer reactions: (i) CD200-CD200R inhibits the expression of CCL8 resulting in the reduction of T reg population and reduction of tumor cell survival, metastasis, and migration [3]; (ii) CD200-CD200R restores the T cell responses [3]; and (iii) CD200 ...

Through this CD200/CD200R signaling pathway, CD200 exerts its immunosuppressive effects by inhibiting natural killer (NK) cell activation, cytotoxic T cell functions, and M1-polarized macrophage activity, while also facilitating expansion of myeloid-derived suppressor cells (MDSCs) and Tregs.

CD200/CD200R are required for maintaining self-tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.

The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric …