OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) [5] is a human protein encoded by the CD200 gene. [6] In humans, the CD200 gene is located on chromosome 3 in proximity to genes encoding the other B7 proteins CD80 / CD86 .

2024年12月24日 · CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include Hairy Cell Leukemia and Indian Tick Typhus. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NECTIN1.

2023年2月4日 · CD200 is an immunoregulatory cell surface ligand with proven pro-tumorigenic credentials via its ability to suppress CD200 receptor (CD200R)-expressing anti-tumor immune function. This definitive role for the CD200-CD200R axis in regulating an immunosuppressive tumor microenvironment has garnered in …

CD200 (formerly termed OX2) is a widely distributed cell surface protein that interacts with a receptor (CD200R) that is highly expressed on myeloid and some lymphoid cells (Wright et al., 2000, 2003). CD200R contains tyrosine motifs that can be phosphorylated.

The cluster of Differentiation-200 (CD200), a 41-47 KDa protein [3-11] characterized by two immunoglobulins superfamily (IgSF) domains , one transmembrane region, and a small cytoplasmic domain, is suggested to be devoid of intracellular signaling function .

CD200 is a transmembrane protein related to the B7 family of costimulatory receptors involved in T-cell signaling and likely plays a role in physiologic immune tolerance. It is normally expressed on lymphoid and neuronal tissue, and its receptor, CD200R, is expressed on antigen-presenting cells and T-cells.

2021年2月5日 · CD200, also known as MRC OX-2, is a highly conserved, 48 kDa [4] type 1a transmembrane glycoprotein related structurally to the B7 family of costimulatory receptors [14], with the gene encoding CD200 located in close proximity to those encoding CD80/CD86 on 3q12-q13 in human (chromosome 16 in mouse) [15, 16].

Supplementing cell-expressed CD200 with soluble recombinant CD200 protein has been effective in reducing inflammation in certain animal models, but the central question is whether there is actually a functional deficit of CD200 on neurons and other cell types in the human brain.

The immunoregulatory protein CD200 as a potentially lucrative yet elusive target for cancer therapy.

Know comprehensive CD200 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.