2023年1月18日 · Here, we found an increase in tumor-infiltrating CD200 + cytotoxic T lymphocytes (CTLs) upon PD-1/PD-L1 blockade, with higher proportions of CD200 + T cells positively related to a favorable clinical outcome to anti-PD-1/PD-L1 therapy in three independent cohorts of patients with cancer.

2023年5月11日 · CD200 is not normally expressed on T cells, so its expression would characterize an aberrant immunophenotype. Few studies have evaluated CD200 expression in T cell neoplasms; however, it appears to be a good immunophenotypic marker for angioimmunoblastic T cell lymphoma .

2021年2月5日 · Expression of CD200 in T cells, both at the mRNA and protein level, is regulated by TNFα and IFN-γ. Both cytokines induce increased CD200 mRNA expression through a 5′ upstream enhancer. TNFα and IFN-γ promote binding of the following trans-acting factors: NF-κBp65(RelA), STAT1α and IRF-1 and -2 to their cis elements.

2023年6月2日 · 该研究发现cd200+t在抗pd-1/pd-l1治疗中具有更好的增殖能力、效应功能，对于t细胞免疫功能恢复至关重要。 而鉴于CD200在肿瘤和免疫细胞上均有表达，对于肿瘤发展呈现出相反的趋势。

2023年1月18日 · Here, we found an increase in tumor-infiltrating CD200 + cytotoxic T lymphocytes (CTLs) upon PD-1/PD-L1 blockade, with higher proportions of CD200 + T cells positively related to a favorable clinical outcome to anti–PD-1/PD-L1 therapy in three independent cohorts of patients with cancer.

2022年11月15日 · Our study demonstrates an immunoinhibitory function of the CD200/CD200R axis in MM. CD200 expression on MM cells leads to reduced primary CD3+ T cell-mediated cytotoxicity via a Dok2-mediated inhibitory mechanism which is accompanied by an increase in Tregs. Our data also indicate that CD200 expression in MM cells may be conveyed by p53.

The overexpression of CD200, expansion of T regulatory (Treg) cell and increased levels of immune modulatory cytokines like IL10, IL6 and transforming growth factor beta (TGFβ) were suggested to have a role in this context.

2024年2月5日 · In this study, using an experimental sepsis model that features immunosuppression, we identified a novel population of pathogenic CD200R high neutrophils that are generated during the initial...

In this chapter, we will give a brief overview of the CD200-CD200R axis, including the biology behind CD200-CD200R interaction and the role(s) it plays in tumor microenvironment and tumor growth, and activation/effector functions of T cells. We will also discuss CD200-CD200R's role as potential checkpoint molecules for cancer immunotherapy.

2012年8月30日 · Via the expression of CD200, T-cells can modulate dendritic cell function and thus interfere with the priming of other T-cell populations. Collectively, by up-regulating CD200 expression in T-cell subsets, MSCs (in particular those derived from WJ tissue) may promote the development of lymphocytes with regulatory phenotypes and thus contribute ...