CD206, also known as mannose receptor C type 1 (MRC1), is a cell-surface protein abundantly presents on selected populations of macrophages and dendritic cells. 16 As for macrophages, CD206 is normally expressed on the M2 but not M1 subtype and therefore serves as a useful marker to identify the M2 phenotype.

2017年8月18日 · We show that adipose tissue CD206 + cells are primarily M2-like macrophages, and ablation of CD206 + M2-like macrophages improves systemic insulin sensitivity, which was associated with an...

2020年2月12日 · CD206 expression status as a surrogate for M2 macrophage population varied considerably across clinical pancreatic cancer resection specimens (Fig. 5A and fig. S23A). CD206 was overexpressed in two of three available independent gene expression sets of clinical pancreatic cancer specimens compared to matched uninvolved normal pancreas, with no ...

This study provided a novel model in which brain microglia are not only derived from yolk sac CD206 − progenitors committed early but also supplied later during brain development/maturation from CD206 + macrophages and suggested the route in which CD206 + cells enter the developing brain parenchyma. We demonstrated a transventricular ...

2019年11月3日 · Further analysis revealed that CD206, a M2 marker gene, could faithfully reflect variation in M2 fractions and was more highly expressed in AML than normal controls. High CD206 expression predicted inferior overall survival (OS) and event-free survival (EFS) in two independent AML cohorts.

We show that CD11b+CD206+ TAM represent the dominant tumor-infiltrating myeloid cell population, expressing a unique cell surface repertoire, promoting Ag cross-presentation and Ag-specific CD8+ T cell activation comparable with cross-presenting CLEC9A+ DCs (cDC1).

2024年11月27日 · CD206 is a common marker of a putative immunosuppressive "M2" state in tumor-associated macrophages (TAMs). We made a novel conditional CD206 (Mrc1) knock-in mouse to specifically visualize and/or deplete CD206+ TAMs.

2025年3月20日 · The numbers of DP-desq, pulmonary expression of CXCL13, IL-1β and CD206 were higher in ILD patients resided for ≥ 15 days per year in places with 24-hour ambient PM10 level of ≥ 50 µg/m3 ...

2019年12月10日 · This study investigated serum soluble CD206 (sCD206) levels in community-acquired pneumonia (CAP) and examined their clinical significance. sCD206 concentrations were measured in the sera of...

CD206 high expression status is associated with decreased intratumoral immunity in human and murine pancreatic cancers. CD206 expression status as a surrogate for M2 macrophage population varied considerably across clinical pancreatic cancer resection specimens (Fig. …