CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin.

2002年5月21日 · In this study, short defined sequences of the CD23a and CD23b proximal promoter regions were used to drive expression of exogenous reporter genes in transiently-transfected B cells exposed to a...

Here we report on a novel human transcription factor, termed nuclear factor IL-4 (NF-IL4), which is posttranslationally activated by IL-4 in lymphoid and monocytic cells. Homologous binding sequences for NF-IL4 were identified in the promoter regions of the IL-4 controlled CD23b and I …

2024年8月21日 · CD23有2种异构体：CD23a和CD23b，二者的不同之处是前者在细胞内有21个氨基酸，后者为22个。 CD23a在B细胞中组成性表达，而CD23b需要 IL-4 在T细胞、单核细胞、朗格汉斯细胞、嗜酸性粒细胞和巨噬细胞上表达。

2024年3月21日 · CD23有2种异构体：CD23a和CD23b，二者的不同之处是前者在细胞内有21个氨基酸，后者为22个。 CD23a在B细胞中组成性表达，而CD23b需要IL-4在T细胞、单核细胞、朗格汉斯细胞、嗜酸性粒细胞和巨噬细胞上表达。

2010年12月1日 · In B cells CD23 has been proposed to play a role in the regulation of IgE synthesis. Two isoforms (CD23a and CD23b) of CD23 have been described [2]. They are generated by alternative transcription initiation sites and differ by the first 6–7 N-terminal amino acids of the intracytoplasmic domain.

Stable human B-cell transfectants expressing either wild-type (WT) CD23b or the genetic variant CD23bR62W were established. When these transfectants were stimulated through CD23, those expressing the genetic variant CD23bR62W (compared with WT CD23b) exhibited higher levels of RNA expression of the RNAs for egr-1 and interleukin-4 receptor α ...

human CD23 gene encodes two protein products differing by six or seven amino acids in the extreme N-terminal cytoplasmic domain. The patterns of expression of CD23a and CD23b transcripts differs...

CD23b is elevated relative to CD23a on B cells of adults exposed to S. mansoni. CD23 exists in two isoforms, detectable only intracellularly by mRNA expression levels. To determine which isoform of CD23 was dominant in schistosomiasis, purified B cells were subjected to RT-PCR for expression of CD23a and CD23b.

2002年10月9日 · Here we identify CD23b promoter as a novel target for NF-AT factors in B-CLL cells. The CD23b promoter contains two NF-AT binding sites to which NF-ATp and NF-ATc factors bind with high affinity. Mutations introduced into these sites abolished NF-AT binding and impaired the promoter activity, as did cyclosporin A (CsA), an inhibitor of nuclear ...