CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils [6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a …

2024年12月24日 · CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Erythroleukemia and Multiple Sclerosis. Among its related pathways are Nervous system development and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.

1978年，科学家首次发现CD24，即分化簇24（Cluster of differentiation 24），也称为热稳定抗原（heat-stable antigen，HSA)，一种高度糖基化的糖基磷脂酰肌醇(GPI)锚定的膜蛋白。CD24没有胞内信号结构域，然而，…

2019年8月5日 · CD24，全称为cluster of differentiation 24，又称热稳定抗原，是一种高度糖基化的糖基磷脂酰肌醇锚定表面蛋白，已知与先天免疫细胞上的 Siglec-10 （sialic-acid-binding Ig-like lectin10）相互作用，以抑制响应感染、败血症、肝损伤和慢性移植物抗宿主疾病的破坏性炎症反应。 然而，也有研究显示， CD24表达于多种实体肿瘤 [4-5]，但该分子在调节肿瘤免疫反应中的作用尚未被证实。 CD24直接保护癌细胞不被巨噬细胞吞噬（图片来源：Nature） 这项新研究证 …

CD24（分化簇24，英語： cluster of differentiation 24 ，也称为热稳定抗原CD24，英語： heat stable antigen CD24 ）是一个人类基因 CD24 编码的蛋白质，是一种细胞粘附分子 [5] 。

Here we show that CD24 can be the dominant innate immune checkpoint in ovarian cancer and breast cancer, and is a promising target for cancer immunotherapy. We demonstrate a role for tumour-expressed CD24 in promoting immune evasion through its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is ...

2019年7月31日 · CD24 interacts with the tumour-associated-macrophage receptor Siglec-10 to inhibit the macrophage-mediated clearance of cancer cells, revealing a new ‘don’t eat me’ signal as a potential ...

2010年2月15日 · In the adaptive immune response, CD24 is a redundant costimulatory molecule in costimulation-rich lymphoid organs but is essential in selected target organs tested, such as brain and skin. More...

2023年11月2日 · Cluster of differentiation 24 (CD24), a mucin-like highly glycosylated molecule has been extensively studied as a cancer stem cell marker in a variety of solid cancers. The functional role of CD24 is either fulfilled by combining with ligands or participating in signal transduction, which mediate the initiation and progression of neoplasms.

CD24, is a mucin-like GPI-anchored molecules. By immunohistochemistry, it is widely detected in many solid tumors, such as breast cancers, genital system cancers, digestive system cancers, neural system cancers and so on. The functional roles of …