2020年12月11日 · 通过CCR7和CD45RA，T细胞可分为四个主要亚群。 这些细胞被命名为初始细胞 (N)、中央记忆细胞 (CM)、效应记忆细胞 (EM)和重新表达CD45RA的终末分化效应记忆细胞 (TEMRA)，尽管体内也可能存在一些中间亚群。 除了这些标记物，CD27和CD28可进一步将T细胞亚群细分如下： •N (CCR7+、CD27++、CD28++、CD45RA+) •CM (CCR7+、CD27++、CD28+、CD45RA−) •EM (CCR7−、CD27+/−、CD28+/−、CD45RA−) •TEMRA (CCR7− …

此外，初始T细胞还高表达其他的细胞表面标志，包括CD27和CD28以及细胞活化的标志CD44和HLA-DR等。 利用多种抗体同时染色细胞并应用流式细胞术在单个细胞水平上分析，其结果表明：只利用一种细胞表面标志（如CD45RA）还不能够准确地鉴别初始T细胞；当同时利用两种表面标志鉴别初始T细胞时，对CD4+T细胞的特异性为97%～98%，CD8+T细胞为87%～93%；当同时利用三种表面标志鉴别初始T细胞时，对CD4+T细胞的特异性为99%，CD8+T细胞为96%。 …

2013年10月30日 · Despite the fact that the expression of CD27 and CD28 tends to be largely co-regulated in humans (although some T TE cells express CD27 but lack CD28), RM T cells are uniformly positive for CD27 in the peripheral blood, independent of their differentiation stage 50 (Roederer and Lugli, unpublished observation).

2002年6月1日 · CD27 and CD28 can be used as cell surface markers to discriminate naive and memory CD8 + T cells from effector CD8 + T cells (6, 7, 8). These molecules are well known as T cell costimulatory molecules. CD28 interacts with CD80 (B7-1) and CD86 (B7-2), which are expressed on APCs (9, 10), and has a dual role as an adhesion and a signaling molecule.

Although the requirement of CD28 and CD27 costimulation has been clearly demonstrated during primary CD8+ T cell responses and this costimulation acts by providing proliferation and survival cues to naive CD8+ T cells, a number of questions also arise from these studies.

就像再生元和赛诺菲开发的CD28多特异性抗体重新让CD28靶点焕发新生一样。 What we have done. 缔码生物目前已成功完成CD27功能抗原制备，CD27参照抗体（Varlilumab biosimilar）制备，以及CD27单克隆抗体分子。

2018年8月1日 · 衰老中的t细胞倾向于失去共刺激分子如cd27和cd28，同时表达杀伤细胞凝集素样受体亚家族g（klrg-1）和cd57。 CD27和CD28下调与人端粒酶RNA组分（hTERC）表达的丧失有关，导致端粒酶活性降低，随后端粒末端的累积受损。

The costimulatory receptors CD27 and CD28 have pivotal and non-redundant roles in the activation and differentiation of γδ T-cells. However, the roles of CD27 and CD28 on γδ T-cells in allergic rhinitis (AR) have remained elusive. The aim of the present study was to investigate the expression of CD27 and CD28 on γδ T cells in patients ...

It was clearly demonstrated that CD27-negative CD8 + CD28 − T cells have the shortest telomeres, show decreased telomerase activity and reduced capacity to proliferate after activation with anti-CD3 and irradiated pAPCs compared with CD27-positive T cells, indicating that CD27-negative CD8 + CD28 − T cells had differentiated to a point ...

2019年9月2日 · 人类CD8＋ T细胞亚群根据CD27、CD28、CCR7、CD45RA的表达，定义出五种不同的循环CD8＋T细胞亚群。 下图中展示了五个亚群之间不同的相对端粒长度、各种细胞表面受体和细胞内分子的表达（与T细胞活化、共刺激、调节、稳态、归巢能力和功能能力相关）。 最末这行表示的是不同种类病毒感染清除之后，留下来的抗原特异性CD8＋T细胞常见表型，这表明不同病毒感染留下来的抗原特异性CD8＋T是有差异的。 点击放大查看原图： 摘录自 …