The protein encoded by this gene is a member of the TNF-receptor superfamily. [11] This receptor is required for generation and long-term maintenance of T cell immunity . It binds to ligand CD70 , and plays a key role in regulating B-cell activation and immunoglobulin synthesis.

2024年12月24日 · CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined T Cell And B Cell Immunodeficiency. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

2025年2月8日 · The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.

缔码生物目前已成功完成CD27功能抗原制备，CD27参照抗体（Varlilumab biosimilar）制备，以及CD27单克隆抗体分子。 而 CD27-mAb B细胞种子库 ，能够快速筛选更多差异化分子，极大节约您的研发周期。

CD27 is a member of the tumor necrosis factor receptor (TNFR) superfamily, which is fundamental in mediating immune responses. Understanding its structure is vital for elucidating its roles in T and B cell activation. CD27 Gene and Protein Structure. The CD27 gene is located on chromosome 12 and encodes a type I membrane protein.

2025年2月8日 · CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion. Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex. CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors.

CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells.

2009年11月24日 · The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory ...

2024年2月13日 · CD27-mediated modulation of TCR signals promoted transcription factor circuits that induced memory rather than effector associated gene programs, which are induced by CD28 costimulation. CD27-costimulated chimeric antigen receptor (CAR)-engineered T cells exhibited improved tumor control compared with CD28-costimulated CAR-T cells.

CD27 deficiency is a rare primary immune deficiency which affects T cells, B cells and NK cells and is associated with hypogammaglobulinemia. Clinical presentation varies from asymptomatic disease to life-threatening Epstein Barr Virus (EBV)-driven complications including malignancy.