2024年12月25日 · PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Angiosarcoma and Hemangioma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is FCRL5.

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. [5][6][7][8] PECAM-1 plays a key role in …

2024年3月1日 · 血小板内皮细胞黏附分子 （英语： Platelet endothelial cell adhesion molecule，缩写 PECAM-1，也称为 CD31，cluster of differentiation 31，分化簇31）是一种细胞表面蛋白质，由人类 17号染色体 上的基因 PECAM1 编码，是 内皮细胞 与 CFU-GM 细胞的主要 标 …

We show that CD31 expression is high on CD34 + hematopoietic progenitors and is quickly reduced after T cell lineage commitment around the early double positive stage (EDP, CD3 − CD1a + CD4 + CD8α + β − cells), likely during expansion post β-selection. CD31 expression then increases and peaks on CD4 + CD8 + DP thymocytes.

PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells. CD31 expression reverts the undifferentiated morphology and aggressive behavior of MDA-MB-231 cells, indicating its active role in …

2020年7月17日 · Triggering of MHC molecules by migrating T-cells is a minimal signal capable of inducing endothelial contraction and transient microvascular leakage. Using this model, we show that EB recovery...

Immunochemical and biochemical characterization, together with its subsequent cloning from two different leukocyte libraries [10, 11] established that the endothelial cell junctional protein, the CD31 hematopoietic differentiation antigen, and platelet PECAM-1 were identical entities, facilitating investigation of the role that this cell ...

CD31又称为血小板-内皮细胞黏附分子（Platelet endothelial cell adhesion molecule-1 ，PECAM-1/CD31），分子量为130kDa，其结构属于免疫球蛋白超家族成员，在清除体内老化的中性粒细胞过程中发挥重要作用。

2025年2月11日 · Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke. CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation.

This evidence suggests a novel mechanism and potential drug target for CD31 in the background of genetic vulnerabilities and peripheral inflammation for AD development and progression. Keywords: Alzheimer's disease (AD), blood–brain barrier (BBB), CD31, neuroinflammation, trans-endothelia Introduction