The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3- gamma, - delta and - zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor - CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] . It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

2024年12月24日 · CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

2020年8月20日 · Collectively, CD3ε is a built-in multifunctional signal tuner, and increasing CD3 diversity represents a strategy to design next-generation CAR. Keywords: CAR-T therapy; Csk; ITAM; T cell receptor; TCR; cancer; cell persistence; cytokine release; p85; phosphorylation pattern; quantitative mass spectrometry. Copyright © 2020 Elsevier Inc.

2025年3月8日 · Title: Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient. Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency.

2024年4月12日 · An inhibitory ligand acts directly on CD3e to regulate T cell activation, and disruption of the interaction boosts tumor-specific T cell cytotoxicity to limit tumor growth.

CD3E is a prognostic marker in Breast invasive carcinoma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, Head and neck squamous cell carcinoma

2017年4月3日 · In this study we have succeeded in establishing a novel mouse strain in which all the three components of the Cd3 complex — Cd3ε, Cd3δ, and Cd3γ — are replaced by their human counterparts, CD3E,...

In this study, we examined the role of CD3ε ITAM-mediated signals in T cell development by genetically reconstituting CD3ε-deficient mice with transgenes encoding either wild-type or ITAM-mutant (signaling defective) forms of the protein.

In this study, we established a humanized CD3E mice by replacing the murine Cd3e gene with the human CD3E gene. The humanized CD3E mice can be used as an effective tool for the efficacy evaluation of CD3E-targeted drugs and toxicological evaluation.