2022年6月14日 · 巨核细胞系的细胞表达血小板膜糖蛋白，如cd41、cd42、cd31、cd61和viii因子。（注：血小板被保存在巨核细胞胞质内的内膜内。血小板膜表面的各种糖蛋白，甚至内容物，如vwf，都来自于巨核细胞，随着血小板的脱落，带走了巨核细胞的细胞质和细胞膜的物质）

2023年4月13日 · Herein we demonstrate MK of single ploidies can be sub-fractionated by antigen expression, such as CD41, into high ploidy large cytoplasmic MK (LCM) and high ploidy small cytoplasmic MK...

2001年4月1日 · To investigate the precise expression of the CD41 antigen during megakaryocyte (MK) differentiation, CD34 + cells from cord blood and mobilized blood cells from adults were grown for 6 days in the presence of stem cell factor and thrombopoietin. Two different pathways of differentiation were observed: one in the adult and one in the neonate cells.

2020年10月2日 · MK-MPs are CD41 + like PMPs; therefore, major circulating CD41 + MPs are derived from 2 sources: activated platelets and MKs 38,39. CD41 + MPs constitute ~70–90% of circulating MPs 40.

Consistent with this notion, thymidine attenuated DNA damage, improved HSC maintenance, and reduced the generation of CD41 + MK-committed HSCs. Replication stress and concomitant MK differentiation is therefore one of the barriers to HSC maintenance.

2023年6月13日 · Our investigation revealed that RUNX1 is required for direct differentiation of MK-HSCs to MK cells, and loss of RUNX1 leads to an increase in the CD41 + MK-HSC subcomposition. Further examination of the function of MK-HSCs via CFU, liquid culture, collagen-based culture, and single cell division assays showed that the …

2024年7月10日 · Plasmacytoid dendritic cells monitor the bone marrow for apoptotic megakaryocytes (MKs) and deliver IFNα to the MK niche, triggering local on-demand proliferation and maturation...

2009年1月2日 · GeneChip and semiquantitative polymerase chain reaction analyses revealed that the Lin − /CD41 + /CD45 + /AChE − MKs are assigned at the stage between the progenitor and PPF preparation phases in respect to the many MK/PLT …

2015年10月1日 · Due to an intrinsic repression of Mk protein synthesis, SL-MkPs express CD41 to similar levels as HSCs during homeostasis, but efficiently induce CD41 expression upon inflammatory signaling.

The objective of this study was to quantify subpopulations of CD34+ cells such as CD41+ and CD42+ cells that might represent megakaryocyte (MK) precursors in peripheral blood stem cell (PBSC) collections of normal, recombinant human granulocyte-colony stimulating factor (rhG-CSF) primed donors and t …