Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene. [5] [6] [7]

2024年3月19日 · Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)

CD43 is a sialomucin transmembrane molecule expressed at high levels on all leukocytes except most resting B lymphocytes. In hematopathology, CD43 is often considered as a T-cell associated marker, because it is expressed by over 95% of thymocytes and peripheral blood T-cells.

The expression of CD43 and CD200 reflects the features of HCL as an indolent malignancy, with protection from apoptosis and cell survival conferred by the effect of CD43, along with immune tolerance granted to the HCL cells due to high levels of CD200.

2018年1月1日 · CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, yet the molecule responsible for this immunodeficiency turned out to be WASP.

CD43 is a highly glycosylated transmembrane protein that regulates T cell activation. CD43−/− T cells are hyperproliferative and the cytoplasmic tail of CD43 has been found to be sufficient to reconstitute wild-type proliferation levels, suggesting ...

2006年9月15日 · CD43 (also known as leukosialin, sialophorin) is one of the most prevalent leukocyte transmembrane sialoglycoproteins 37 expressed exclusively on cells of hematopoietic lineage, including hematopoietic stem cells, 38 but excluding mature erythrocytes and B-cell subsets. 26,28 CD43 has a highly conserved across species cytoplasmic domain and ...

CD43, a surface glycoprotein, regulates Mycobacterium tuberculosis macrophage binding, replication, and proinflammatory cytokine induction in a murine model. We hypothesized that single-nucleotide polymorphisms (SNPs) in the CD43 gene region are associated with human tuberculosis (TB) susceptibility.

1999年12月12日 · In a screen designed to identify genes that regulate T cell receptor (TCR)/CD3-mediated apoptosis, we found that high level expression of CD43 protected T cell hybridomas from activation-induced cell death.

2016年10月12日 · CD43 co‐stimulation does not enhance pyruvate kinase glycolytic activity. Cellular signalling efficacy ultimately depends on the integration of internal metabolic cues. Particularly, T‐cell activation calls for higher levels of biosynthetic precursors and energy for effector functions.