The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and standard) isoform, and HA-CD44 binding consider as an attractive and …

In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) and the uptake of hyaluronic acid (HA)-based materials, which are …

An abundance of HMW HA can promote malignant cell proliferation and development of cancer, whereas antagonists to HA-CD44 signaling inhibit tumor cell growth in vitro and in vivo by interfering with HMW HA-CD44 interaction. This review describes the roles of HA interactions with CD44 and RHAMM in inflammatory responses and tumor development ...

cd44以ha依赖性或ha非依赖性参与调节 mmps 表达，特别是mmp2和mmp9，降解细胞外基质（ecm），促进肿瘤的侵袭和转移。 cd44调节细胞周期相关蛋白的水平，包括细胞周期蛋白d和细胞周期蛋白a。

CD44和HA介导的运动受体（RHAMM）是两个主要的HA受体，已经全面研究了其在人和鼠炎症和肿瘤细胞中的生物学功能。 HA最初被认为只是结缔组织的惰性成分，但现在被称为“动态”分子，通过涉及各种大小的HA分子的快速代谢，在许多组织中具有恒定的更新率：高分子量HA（HMW HA） ，低分子量HA和寡糖。 HA与CD44和RHAMM相互作用引发的细胞内信号转导通路导致炎症反应和致瘤反应很复杂。 有趣的是，这些分子在炎症和肿瘤发生中具有双重功能。 例如，关 …

2018年5月10日 · HA-drug bioconjugates, such as HA-Taxol, HA-CPT11, HA-Paclitaxel (PTX), and HA-polymer conjugates, can efficiently bind to CD44 overexpressing cancer cells and exert strong anti-proliferative activity on CD44 overexpressing cancer cells including human breast, colon, ovarian, gastric, breast, esophageal, and lung cancer cells as well as rat ...

2020年10月6日 · Our results revealed that an ER-CD44-HA signaling circuit that mediates robust compensatory activation of the Src-ERK signaling cascade may contribute to the development of acquired resistance to...

2015年5月6日 · An abundance of HMW HA can promote malignant cell proliferation and development of cancer, whereas antagonists to HA-CD44 signaling inhibit tumor cell growth in vitro and in vivo by interfering with HMW HA-CD44 interaction. This review describes the roles of HA interactions with CD44 and RHAMM in inflammatory responses and tumor development ...

2017年5月1日 · HA is used by several investigators as a vehicle to transport anticancer drugs for at least three reasons. First, HA binds CD44 variants. Second, HA-drug conjugate is concentrated on the cell surface and internalized. Third, toxicity due to …

2017年3月6日 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …