Markers for human haematopoietic stem cells: The disconnect …
The integrin alpha chain subunit protein, CD49f, was identified in 2011 as a marker that could be used to further purify the Lin − CD34 + CD38 − CD45RA − CD90 + HSC population to 1 in …
Mapping human haematopoietic stem cells from haemogenic
2022年4月13日 · Clusters with haematopoietic cells (RUNX1 + CD45 +) and HSCs (cluster 12) are indicated by purple and black circles, respectively. Feature plots identify HSCs by the co …
Tracing haematopoietic stem cell formation at single-cell ... - Nature
2016年5月18日 · Here we use a novel combination of surface markers to isolate individual functional CD45 − and CD45 + pre-HSCs in the E11 mouse aorta–gonad–mesonephros …
Flow cytometry analysis of murine hematopoietic stem cells
2012年6月26日 · Progeny of donor HSC (CD45.2) can be discriminated from recipient cells (CD45.1) by CD45 alleles, and the donor HSCs that were successfully transduced to over …
Epitope base editing CD45 in hematopoietic cells enables ... - AAAS
2023年8月31日 · Epitope-edited CD45 CAR T cells were fratricide resistant and effective against patient-derived acute myeloid leukemia, B cell lymphoma, and acute T cell leukemia. Epitope …
文献解析|CD45靶点：深入解析与应用探讨
2024年11月29日 · 通过同步编辑CAR-T细胞和HSC表面的CD45，研究者构建了一个潜在的临床治疗方案，该方案首先利用CD45 CAR-T细胞清除患者体内的血液肿瘤细胞，随后通过移植经过 …
【讨论】一个HSCs的CD34和CD45的问题。 - DXY.cn
2006年11月9日 · 在用CD34标记HSC的时候，一般要选CD45阴性或若阳性。 CD45是所有有核细胞的标记，HSC没有核？ 还是不表达？ CD45在这里的作用到底是什么？ 就想要CD45阴性的 …
CD45靶点 - 知乎 - 知乎专栏
2023年9月20日 · Iomab-B是由Fred Hutchinson癌症研究中心开发的一款靶向CD45的核药，旨在通过同时快速耗竭特异性表达CD45的血液癌、免疫细胞和骨髓干细胞来增加患者接 …
CD45 in the Stem Cell Niche - R&D Systems
CD45 dephosphorylates and downregulates the activity of Src family kinases (SFK) on hematopoietic stem cells (HSCs). This decreases integrin activity and adhesion as occurs, for …
Surface antigen phenotypes of hematopoietic stem cells from ... - PubMed
2009年7月9日 · ESC-HSCs express CD41 and CD150, lack CD34, and are heterogeneous for CD45. Finally, although CD48 was absent from all in vivo HSCs examined, ESC-HSCs were …