Csk是Y505的磷酸化激酶（负调控Lck活性），CD45则负责去磷酸化激活Lck。CD45是几乎所有白细胞都表达的一类跨膜蛋白，其胞内部分具有磷酸水解酶活性。去磷酸化后的Lck处于半开放 …

The increased sensitivity of CD45-sufficient cells can be attributed to the role of CD45 in activating Lck. When cells are CD45 deficient, low basally active Lck amounts propagate through the …

2020年6月21日 · 蛋白酪氨酸磷酸酶CD45可以使Lck的C端Y505去磷酸化，从而使Lck可以通过反式自磷酸化激活。 当CD45缺陷时，Lck处于自抑制失活构象，TCR信号减弱，胸腺发育受阻。

2002年12月23日 · We propose that truncation of the CD45 ectodomain reduced the access of CD45 to Lck in GEMs, which increased the closed pTyr 505 form of Lck, thereby resulting in …

2017年8月3日 · Our findings reveal that modification of Y192 inhibits the ability of CD45 to associate with Lck in cells and dephosphorylate the C-terminal tail of Lck, which prevents its …

2014年10月10日 · T cell receptor (TCR) phosphorylation requires the kinase Lck and phosphatase CD45. CD45 activates Lck by dephosphorylating an inhibitory tyrosine of Lck to …

2019年10月22日 · T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen …

2004年1月30日 · Analysis of the interaction between the cytoplasmic domain of CD45 and its substrate, Lck, revealed that the active, membrane-proximal phosphatase domain of CD45 …

We propose that high wild-type CD45 expression is necessary to dephosphorylate p56 (lck) pTyr-394, suppressing CD4 T+ cell lineage commitment and hyperactivity. The molecular …

2007年9月21日 · To investigate this question, we have reconstituted CD45 (encoded by Ptprc)-deficient mice, which display severe defects in thymic development, with five different …