PTPRC - Wikipedia
The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular …
Protein tyrosine phosphatase receptor type C (PTPRC or CD45)
The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic …
PTPRC Gene - GeneCards | PTPRC Protein | PTPRC Antibody
2024年12月25日 · PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Immunodeficiency 105, Severe Combined …
Protein tyrosine phosphatases and the immune response
2005年1月1日 · CD45, SHP2 (SRC homology 2 (SH2)-domain-containing PTP 2), and LMPTP (low-molecular-weight PTP) mainly have positive roles in signalling through the T-cell receptor.
CD45 (PTPRC)靶点介绍及实验小贴士| Abcam中文官网
CD45缺乏会导致T淋巴细胞和B淋巴细胞功能障碍，表现为严重的联合免疫缺乏。 在自身免疫性疾病、癌症以及感染性疾病中，CD45也起着重要作用。 在骨髓、淋巴结、脾脏、扁桃体等部位 …
PTPRC protein tyrosine phosphatase receptor type C [ (human)]
Studies indicate that CD45, nonreceptor SH2 domain-containing PTP-1 (SHP-1) and PEST domain-enriched tyrosine phosphatase (PEP) are expressed at elevated levels in immune …
CD45 is a JAK phosphatase and negatively regulates cytokine
2001年1月18日 · Here we show that CD45 suppresses JAK (Janus kinase) kinases and negatively regulates cytokine receptor signalling. Targeted disruption of the cd45 gene leads …
C型蛋白酪氨酸磷酸酶受体（PTPRC或CD45）,Journal of Clinical …
2021年9月1日 · 白细胞共同抗原 C 型蛋白酪氨酸磷酸酶受体 (PTPRC)，又称 CD45，是一种跨膜糖蛋白，在除成熟红细胞外几乎所有造血细胞上均有表达，是 T 细胞和 B 细胞抗原受体介导 …
CD45靶点 - 知乎 - 知乎专栏
2023年9月20日 · 2023年8月31日，宾夕法尼亚大学Saar Gill 教授、Carl June 教授研究团队在Science 子刊 Science Translational Medicine 上发表了题为Epitope base editing CD45 in …
Protein tyrosine phosphatase receptor type C (PTPRC or CD45)
The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic …