CD47 Promotes Tumor Invasion and Metastasis in Non-small …
2016年7月14日 · In order to assess the effect of CD47 on in vivo tumor metastasis, A549 transfected with control shRNA or CD47-shRNA was injected through the tail vein and …
Human lung adenocarcinoma CD47 is upregulated by interferon-γ …
2022年6月16日 · To determine the effect of IFN-γ-mediated upregulation of tumor cell CD47 on tumor metastasis in vivo, we established a lung cancer cell metastasis model using …
Regulation of CD47 expression by interferon-gamma in cancer …
In A549 and NCI-H1975 cells, RT-PCR was to detect mRNA expression of CD47 (a), western blot was applied to detect the CD47 protein expression (b), flow cytometry was used to detect cell …
RAGA prevents tumor immune evasion of LUAD by promoting CD47 …
2023年2月23日 · CD47 is a macrophage-specific immune checkpoint protein acting by inhibiting phagocytosis. However, the underlying mechanism maintaining CD47 protein stability in …
Frontiers | Development of Novel CD47-Specific ADCs Possessing …
2022年5月11日 · These CD47-specific ADCs have the better cell penetration, excellent DAR, similar payload distribution and good antigen-binding affinity. In vitro, 7DC-VCMMAE treatment …
CD47-mediated immune evasion in early-stage lung cancer …
2024年8月6日 · CD47 expression levels were evaluated in four human lung cancer cell lines: A549, which harbors wild-type epidermal growth factor receptor (EGFR) and wild-type p53; …
Dual blockade of GSTK1 and CD47 improves macrophage …
3 天之前 · However, in some cases, blocking CD47 alone is insufficient to fully activate macrophage and trigger a robust anti-tumor response, implying the presence of additional, …
CD47: The Next Frontier in Immune Checkpoint Blockade for Non …
2023年10月31日 · Knockdown of CD47 using shRNA or siRNA in A549 cells or tumor xenografts, as well as shRNA in a Kras–Trp53-driven genetically engineered mouse model of LUAD, was …
[The Role of TSP-1-CD47 in ROS-mediated Pulmonary Fibrosis ... - PubMed
2018年9月20日 · Objective: Taking human A549 cells as the research object, to construct the paraquat-induced pulmonary fibrosis model in vitro, and to explore the role of TSP-1 …
Blocking CD47 efficiently potentiated therapeutic effects of …
2019年12月11日 · Our research provided evidence that CD47 blockade could sensitize NSCLC to anti-angiogenic therapy and potentiate its anti-tumor effects by enhancing macrophage …