CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily [5] and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). [6]

Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol.

2023年11月9日 · Here we found that, in addition to triggering SIRPα, CD47 suppressed phagocytosis by a SIRPα-independent mechanism. This mechanism prevented phagocytosis initiated by the pro-phagocytic ligand,...

Topological arrangements of CD47 and its known extracellular ligands. (A) Thrombospondin-1 (TSP1) is a secreted protein that binds to a proteoglycan isoform of CD47 on the plasma membrane. Mutagenesis studies established that heparan sulfate modification of CD47 is required for high affinity interaction of TSP1 with CD47.

CD47-ligation promotes translocation of pro-apoptotic BNIP3 and Drp1 to the mitochondria, as well as inducing concurrent increases in Mcl1 and NOXA protein levels in a manner preventing cytochrome c release and caspase activation.

2012年1月22日 · CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer. CD47 is a ligand for SIRPα, a protein expressed on macrophages and dendritic cells. In vitro, blockade of CD47 signaling using targeted monoclonal antibodies enabled macrophage phagocytosis of tumor cells that were otherwise protected.

1 天前 · However, in some cases, blocking CD47 alone is insufficient to fully activate macrophage and trigger a robust anti-tumor response, implying the presence of additional, unidentified phagocytosis checkpoints that resist the macrophage activity [14], [15].The discovery and blockade of these phagocytic checkpoints might effectively improve the phagocytic efficiency and anti-tumor effects of CD47 ...

2020年4月2日 · CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα. Biologics, including humanized CD47 monoclonal antibodies and decoy SIRPα receptors, that block the SIRPα-CD47 interaction, are currently being developed as cancer immunotherapy agents.

2001年9月14日 · CD47 is an Ig superfamily member involved in signaling from both cell-cell and cell-ECM interactions. Coligation of CD47 and the T cell antigen receptor (TCR) is a synergistic signal for activation of T lymphocytes (1, 2, 3) that requires CD47-induced association of protein kinase Cθ with cytoskeleton (3).

Ligation of CD47 can induce intracellular signaling resulting in cell activation or cell death depending on the exact context. By binding to another cell surface glycoprotein, signal regulatory protein alpha (SIRP α), CD47 can regulate the function of …