SIRPα/CD47 axis controls the maintenance of transplant ... - PubMed
Here, we found that blocking SIRPα or CD47 with monoclonal antibodies (mAbs) induced differentiation of MDSC into myeloid cells overexpressing MHC class II, CD86 costimulatory …
SIRPα/CD47 axis controls the maintenance of transplant tolerance ...
2019年6月17日 · Here, we found that blocking SIRPα or CD47 with monoclonal antibodies (mAbs) induced differentiation of MDSC into myeloid cells overexpressing MHC class II, CD86 …
Disruption of CD47-SIRPα signaling restores inflammatory …
2024年4月19日 · Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive properties via signal-regulatory protein alpha …
CD47-SIRPα信号传导的破坏可恢复肿瘤相关骨髓源性抑制细胞的 …
在这里，我们探讨了肿瘤微环境通过信号调节蛋白 α (sirpα)/cd47 信号传导调节 mdsc 分化和免疫抑制特性的作用。 在小鼠黑色素瘤模型中，我们观察到单核细胞 MDSC 和单核细胞衍生的树 …
Molecular cargo in myeloid-derived suppressor cells and their …
CD47 on MDSC-derived exosomes contributes to the chemotaxis of parental MDSC. We consider the accumulation of MDSC in the tumor microenvironment to be critical for immune …
Anti-CD47 treatment enhances anti-tumor T-cell immunity and …
Furthermore, inhibition of CD47 delayed tumor growth and improved tumor microenvironment by stimulating effector T cells and decreasing suppressive immune cells and regulating the …
Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That …
In vitro studies demonstrated that exosomal CD47 served as a powerful chemotactic signal for parental MDSC with thrombospondin-1 being the predominant ligand and SIRPα playing a …
巨噬细胞的免疫检查点：CD47-SIRPα - 知乎 - 知乎专栏
cd47是sirpα最主要的配体，其它的配体包括：表面活性蛋白a和d（sp-a和sp-d）。目前sirpα被研究的最透彻的功能是其抑制巨噬细胞的吞噬功能； cd47分子和sirpα分子结构以及信号通路示 …
Interaction of SIRP alpha (SIRPα), expressed by myeloid cells, with the ubiquitous receptor CD47 is an important immune checkpoint of the innate response regulating macrophages and …
PD-L1 和 CD47 的双重阻断增强了奥沙利铂和 FOLFOX 在 CT-26 小 …
这种三联方案还导致肿瘤微环境中 treg 和 mdsc 的显着减少以及 cd8 + inf-γ + 淋巴细胞和 m1/m2 巨噬细胞比率的显着增加。我们的研究表明，folfox、cd47 和 pd-l1 的三联疗法在 ct-26 小鼠 …