2021年6月28日 · CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesi …

2018年10月10日 · In addition, CD47 was found to be required for neuronal activity-mediated changes in engulfment, as microglia in CD47 knockout mice failed to display preferential engulfment of less active inputs. Taken together, these results demonstrate that CD47-SIRPα signaling prevents excess microglial phagocytosis and show that molecular brakes can be ...

2021年4月1日 · Microglia play a key role in regulating synaptic remodeling in the central nervous system. Activation of classical complement pathway promotes microglia-mediated synaptic pruning during development...

During neurological disorders, CD47 functions as a key neuroimmune modulator responding to chronic and acute CNS injuries and in the process of recovery [5, 8]. Additionally, CD47 has broad involvement in the death of neuronal cells, inflammation, and the development of acute ischemic brain injuries [9, 10].

2018年10月10日 · CD47 receptor SIRPα (SHPS-1/CD172a/P84/BIT/MyD-1) is an Ig superfamily protein expressed by phagocytes in the peripheral immune system that has been observed on microglia and neurons in the CNS (Adams et al., 1998).

We have now investigated the role of the transmembrane protein cluster of differentiation 47 (CD47) in this process with hippocampal neurons. CD47-deficient neurons manifested markedly impaired development of dendrites and axons, whereas overexpression of …

signaling prevents excess microglial phagocytosis during developmental synaptic pruning. They find that CD47 is required for neuronal activity-mediated changes in microglial engulfment and that mice lacking CD47 display increased structural and functional pruning.

2022年12月13日 · Global CD47 deficiency modestly increased microglial phagocytosis, while CD47 overexpression reduced it. This effect was rescued by coexpression of neuronal SIRPα or codeletion of neuronal SIRPα and CD47. These data indicate that neuronal SIRPα regulates microglial phagocytosis by limiting microglial SIRPα access to neuronal CD47.

2022年12月13日 · Global CD47 deficiency modestly increased microglial phagocytosis, while CD47 overexpression reduced it. This effect was rescued by coexpression of neuronal SIRPα or codeletion of neuronal SIRPα and CD47. These data indicate that neuronal SIRPα regulates microglial phagocytosis by limiting microglial SIRPα access to neuronal CD47.

We will discuss the involvement of SIRP/CD47 signaling in microglial activation and in the interplay between microglia and other CNS cells. Current studies reveal the importance of CD47 and SIRPα in the process of neuroinflammation in the CNS disorders.