cd47是sirpα最主要的配体，其它的配体包括：表面活性蛋白a和d（sp-a和sp-d）。目前sirpα被研究的最透彻的功能是其抑制巨噬细胞的吞噬功能； cd47分子和sirpα分子结构以及信号通路示意图. cd47-sirpα免疫检查点的作用机制

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily [5] and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). [6]

This review addresses recent advances in identifying the lateral binding partners, signal transduction pathways and downstream transcription networks regulated through CD47 in specific cell lineages. Major pathways regulated by CD47 signaling include calcium homeostasis, cyclic nucleotide signaling, nitric oxide and hydrogen sulfide ...

2012年4月24日 · CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer. CD47 is a ligand for SIRPα, a protein expressed on macrophages and dendritic cells. In vitro, blockade of CD47 signaling using targeted monoclonal antibodies enabled macrophage phagocytosis of tumor cells that were otherwise protected.

2020年5月19日 · The protein CD47, expressed on both healthy and malignant cells, delivers a “don’t eat me signal” upon binding to the SIRPα receptor on myeloid cells. Schumacher and colleagues discuss the current understanding of the role of the CD47-SIRPα axis in physiological tissue homeostasis and as a promising therapeutic target in, among others ...

2024年7月23日 · CD47 is a ubiquitously expressed cell surface receptor, which is widely known for preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein α (SIRPα) on the...

CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy. ⁣Recently, CD47 has been shown to play a role as a signaling receptor, involving a ...

Major pathways regulated by CD47 signaling include calcium homeostasis, cyclic nucleotide signaling, nitric oxide and hydrogen sulfide biosynthesis and signaling, and stem cell transcription factors.

4 天之前 · CD47 is a crucial anti-phagocytic signal in regulating macrophage responses and its manipulation offers the therapeutic potential in cancer treatment. However, in many cases, blockade of CD47 by itself is insufficient to activate macrophage effectively, indicating other unidentified phagocytosis-regulating factors to resist the macrophage activity.

CD47, a widely expressed transmembrane protein, is a ligand for SIRPalpha, with the two proteins constituting a cell-cell communication system. The interaction of SIRPalpha with CD47 is important for the regulation of migration and phagocytosis.