Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands …

2017年2月21日 · Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that …

Here, we found that tumor-infiltrating CD8 + T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth. This differentiation sequence was driven …

Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8+ …

2017年2月21日 · CD49a constitutes the α-subunit of the α 1 β 1 integrin receptor, also known as very late antigen 1 (VLA-1), and binds collagen IV enriched in the basement membrane …

CD49a regulates the early adhesion and migration of dNK cells into trophoblast, and forestall their cytotoxicity by downregulating the expression of perforin, granzyme B and IFN-γ. In dNK cells …

2020年9月1日 · CD8 + T RM expressing the α1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that …

2025年1月9日 · Blockade of CD49a using an mAb suppressed tumor development in mice, and combination treatment with anti-PD-L1 further enhanced antitumor efficacy. Our research …

2017年2月21日 · CD49a constitutes the α-subunit of the α1 β 1 integrin receptor, also known as very late antigen 1 (VLA-1), and binds collagen IV enriched in the basement membrane …

Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) …