1996年9月1日 · Our data demonstrate that CD5 and CD72 molecules are coexpressed with other ligand pairs usually involved in T-B cell cognate interaction on B-1a cells, but not on B-2 cells. CD5 and/or CD72 engagement delivers critical costimulatory signals in B-1a, B-2, and B cells from patients with chronic lymphocytic leukemia, but with different ...

1991年6月20日 · The results demonstrate that the B-cell surface protein CD72 (Lyb-2 in mice) is the ligand for CD5. THE glycoprotein CD5 is expressed on the surface membrane of all mature T cells1 and a...

1996年9月1日 · Our data demonstrate that CD5 and CD72 molecules are coexpressed with other ligand pairs usually involved in T-B cell cognate interaction on B-1a cells, but not on B-2 cells. CD5 and/or CD72 engagement delivers critical costimulatory signals in B-1a, B-2, and B cells from patients with chronic lymphocytic leukemia, but with different ...

A neutralizing antibody was used to determine the role of CD5 and CD72 in maintaining regulatory T and B cell homeostasis. We found that CD19(+)CD5(+)CD1d(hi) Bregs induced expansion of CD4(+)Foxp3(+) Tregs, and CD4(+)CD25(+) Tregs also induced expansion of …

2010年11月15日 · The cell surface binding partner for CD5 purified from cells was identified as CD72 . An interaction between CD72 and CD5 has not been reproduced. Soluble recombinant CD5 did not bind cell surface CD72 (15–17), and there was no evidence for productive engagement of cell surface-expressed CD5 and CD72 .

2023年3月1日 · 近日，美国密歇根大学的Eynav Klechevsky团队在《Science》杂志上发表了名为“CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses”的文章。在这篇文章中，作者阐明了免疫检查点阻断（Immune checkpoint blockade，ICB）的工作机制，并提出表达CD5的DC可 ...

2024年12月24日 · CD72 (CD72 Molecule) is a Protein Coding gene. Diseases associated with CD72 include Systemic Lupus Erythematosus and Leukemia, Chronic Lymphocytic. Among its related pathways are Nervous system development and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and …

1992年3月15日 · In this report, we describe the purification of mouse CD5 protein (mCD5) and its use as a probe to search for the ligand of CD5. We demonstrate that mCD5 specifically interacts with the mouse B cell differentiation Ag CD72/Lyb-2. Three serologically defined allelic forms of mouse CD72/Lyb-2 can all interact with mCD5.

2014年12月16日 · Our previous study demonstrated that interaction of CD5 and CD72 is involved in T reg and B reg homeostasis . To determine whether the interaction between CD5 and CD72 was also involved in thymic B reg-mediated maintenance of T regs, neutralizing anti-mouse CD72 antibodies were used to block the CD5–CD72 interaction. First, we test the ...

ered that CD5, a 67-kDa transmembrane protein expressed on all T cells as well a subgroup of B cells (CD5 or B1” cells), is a natural ligand of CD72 (17-19). This find- ing suggests that CD72 and CD5 may play an important role in B and T cell cross-talk, and their interaction may