Flow cytometry demonstrated a 54% population of NK cells, that are CD2(dim +), CD3(−), CD7(−), CD4(−), CD5(−), CD8(predominantly −), CD16(−), CD56(bright +), CD57(−), and CD94(bright +).

11 小时之前 · 近日，gc cell宣布启动其新型cd5 car-nk细胞疗法 gcc2005 （ab-205）的1 期临床试验。 什么是car-nk细胞疗法. nk细胞是机体重要的免疫细胞，是肿瘤免疫监视的重要组成部分，能够迅速识别，对感染或肿瘤的出现做出反应，并攻击肿瘤细胞。

Human NK cells do not usually express CD5 antigen, but we found a novel subset of CD5LOW (low density of CD5) positive (CD5LOW+) natural killer cells (NK cells) in patients with multiple myeloma (MM) and plasmacytoma. To detect CD5LOW+NK cells, we examined the lymphocytes of 23 patients with MM and plasmacytoma by flow cytometry.

2024年10月26日 · CD5, a common surface marker of malignant T cells, has three scavenger receptor cysteine-rich domains (D1-D3) in the extracellular region. The present study aims to construct “off‑the‑shelf” CAR-NK cells targeting the membrane-proximal domain of CD5 derived from nanobody against T-cell malignancies.

2017年1月12日 · We found that CD5CAR NK-92 cells possessed consistent, specific, and potent anti-tumor activity against a variety of T-cell leukemia and lymphoma cell lines as well as primary tumor cells....

2023年5月25日 · In a recent study published in Science, He et al. investigated the role of CD5 on dendritic cells (DCs) in priming effector T cells. 1 By proving the importance of CD5 in engaging effective...

2019年5月16日 · CD5 CAR-NK cells, especially those constructed with the intracellular domain of NK-cell-associated activated receptor-2B4, exhibited specific cytotoxic properties against CD5 + malignant cells in vitro and remarkably prolonged the survival of T-ALL xenograft mice in vivo. 2B4.z-NK could be a potential immunotherapy strategy for T cell ...

2019年5月16日 · Results: Both BB.z-NK and 2B4.z-NK exhibited specific cytotoxicity against CD5 + malignant cells in vitro and prolonged the survival of T-ALL xenograft mice. Encouragingly, 2B4.z-NK cells displayed greater anti-CD5 + malignancy capacity than that of BB.z-NK, accompanied by a greater direct lytic side effect versus BB.z-NK.

2018年7月31日 · 在nk细胞上，cd160主要表达在细胞毒亚群中(cd56dim/cd16+)，增强细胞活化和细胞毒能力，启动ifn-γ、il-6、il-8、tnf-α等分泌。 CLL中有些B细胞可表达CD160，从而增强细胞存活和活化，导致IL-6产生。

2023年3月1日 · CD5是一种跨膜糖蛋白，作为小鼠和人类中DC亚群的标志物，在T细胞受体信号传导及其外周效应器功能中发挥重要作用。 然而，CD5在DC上的生理学作用以及这种CD5+ DCs对肿瘤免疫的影响尚不清楚。 鉴于该在团队之前的工作发现了人皮肤中的CD5+ DCs比CD5缺失的DCs（CD5- DCs）更有效地激发辅助T细胞和多功能细胞毒性T细胞，他们假设在炎症环境中CD5+ DCs的增加与其参与抗肿瘤反应，以及对ICB的治疗反应相关。 1. CD5表达与改善黑色素瘤患 …