2024年7月26日 · 有研究报告了一种新的机制，其中cd51被γ-分泌酶复合物直接切割以产生细胞内结构域（cd51-icd）。 该研究发现CD51-ICD通过增强氧化磷酸化（OXPHOS）来促进肿瘤进 …

ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage …

2016年9月5日 · CD51 knockdown reduced the side population, sphere formation, cell motility and inhibited tumor incidence and metastasis in an in vivo tumor model. Furthermore, CD51 could …

设立分化簇 (CD) 命名系统的目的是对白细胞表面抗原进行分类。 最初，表面抗原是根据与它们结合的对应单克隆抗体进行命名。 随着各实验室逐渐发现抗原常能刺激产生多种单克隆抗体， …

2023年8月28日 · 该研究发现整合素家族蛋白CD51促进肝细胞癌远处转移的全新机制，为以整合素为靶点的综合肿瘤治疗提供了重要理论支撑，开拓了未来发展思路，具有很强的临床转化价值 …

CD51 knockdown reduced the side population, sphere formation, cell motility and inhibited tumor incidence and metastasis in an in vivo tumor model. Furthermore, CD51 could bind …

CD51 is a transmembrane glycoprotein of the integrin family that plays a role in cell adhesion, migration, tumorigenesis, and other cellular functions. In this study, we aimed to investigate …

2018年5月9日 · Here we demonstrate that CD51, in part, correlates with the poor prognosis of PCa patients. Further, we find that CD51 is a functional molecule that is able to promote the …

This study reveals that the γ-secretase complex directly cleaves CD51 to produce an intracellular domain (CD51-ICD), which functions as a pro-tumoral transcriptional regulator and can bypass …

2023年6月18日 · CD51 is a transmembrane glycoprotein of the integrin family that plays a role in cell adhesion, migration, tumorigenesis, and other cellular functions. In this study, we aimed to …