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Wikipedia
https://en.wikipedia.org › wiki
CD6 - Wikipedia
CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene. This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for c…
Clinical significance
Certain alleles of this gene may be associated with susceptibility to multiple sclerosis. 展开
See also
• Cluster of differentiation 展开
外部IDOMIM：186720 MGI：103566 HomoloGene：4893 GeneCards：CD6
别名CD6；, TP120, CD6 molecule
Further reading
• Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. … 展开
External links
• CD6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser.… 展开
CC-BY-SA 许可证中的维基百科文本

GeneCards
https://www.genecards.org › cgi-bin › carddisp.pl
CD6 Gene - GeneCards | CD6 Protein | CD6 Antibody
2024年12月24日 · CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Multiple Sclerosis and Graft-Versus-Host Disease. Gene Ontology (GO) annotations …
搜狐
https://www.sohu.com
新药巡礼：孤独的前行者，itolizumab与冷门靶点CD6 - 搜狐
2021年12月27日 · 本文介绍了CD6-ALCAM通路在自身免疫反应中的作用，以及itolizumab等抗体药物对该通路的阻断作用。特别关注了itolizumab在移植物抗宿主病（GvHD）和多种自身免 …

Abcam中文官网

https://www.abcam.cn › primary-antibodies

人 CD 抗原完全指南 - Abcam中文官网

413 行 · 本网页介绍了人类白细胞分化簇 (CD) 抗原的命名系统、细胞表达、功能和产品信息 …

靶标名称	别名	细胞表达	功能
CD5	LEU1	胸腺细胞、T 细胞和 …	调控 T 细胞与B 细胞的相互作用。 …
CD6	OX52、T12、TP120	胸腺细胞、T 细胞和 …	参与胸腺细胞发育并可能与 T ...
CD7	LEU 9、GP40、TP41	胸腺细胞、T ...	T 细胞共刺激。与 SECTM1 ...
CD8a	MAL	胸腺细胞亚群、细胞 …	MHC I 类分子的共受体。

查看www.abcam.cn的所有413行

PubMed
https://pubmed.ncbi.nlm.nih.gov
CD6 as a Cell Surface Receptor and As a Target for Regulating …
CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long …
- 作者: Marion H Brown
- Publish Year: 2016

Nature
https://www.nature.com › articles
The role of CD6 in autoimmune diseases - Nature
2018年3月23日 · Hypomethylation of CD6 in an autoimmune disease has been shown in the vasculitic lesions of giant cell arteritis, together with hypomethylation of various other genes …
其他用户还问了以下问题
Is CD6 a human protein?
CD6 (C luster of D ifferentiation 6) is a human protein encoded by the CD6 gene. This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule.
CD6 - Wikipedia
en.wikipedia.org
Why is CD6 used as a drug target?
CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long cytoplasmic tail. CD6 can affect both the initiation and maintenance of T cell function in a negative a …
CD6 as a Cell Surface Receptor and As a Target for Regulating Immune
pubmed.ncbi.nlm.nih.gov
Is CD6 methylated in giant cell arteritis?
Hypomethylation of CD6 in an autoimmune disease has been shown in the vasculitic lesions of giant cell arteritis, together with hypomethylation of various other genes related to T cell activation and effector T cell differentiation. 4
The role of CD6 in autoimmune diseases - Nature
nature.com
Where is CD6 detected?
Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
CD6 Gene - GeneCards | CD6 Protein | CD6 Antibody
genecards.org
How does CD6 affect EAE?
The CD6-deficient mice have both a reduction in the Th1/Th17 response to myelin antigens and decreased infiltration of tissue-damaging immune cells in the central nervous system. 7 The involvement of CD6 itself in EAE was further demonstrated in CD6–/– mice in which a human CD6 transgene was expressed in T cells.
The role of CD6 in autoimmune diseases - Nature
nature.com
Is CD6 soluble or transmembrane?
CD6, CD166, and CD318 all exist in soluble and trans-membrane forms, and the soluble forms may also be important in disease.
The role of CD6 in autoimmune diseases - Nature
nature.com
反馈
维基百科
https://zh.wikipedia.org › wiki
CD6 - 维基百科，自由的百科全书
CD6（cluster of differentiation 6，分化簇6）是一种细胞表面蛋白质，由人类基因 CD6 编码 [6] ，主要在T淋巴细胞等免疫细胞上表达 [7] 。
搜狐
https://www.sohu.com
CD6蛋白与细胞信号传导—艾普蒂生物 - 搜狐
2024年9月13日 · cd6蛋白是一种重要的免疫系统受体，主要在t细胞表面表达。它在免疫细胞的激活、增殖、分化以及免疫调节中发挥关键. 作用。cd6不仅在免疫应答中扮演重要角色，还涉及 …
MCE-生物活性分子大师
https://www.medchemexpress.cn › gene
CD6 分子（CD6）基因 | MCE - MCE-生物活性分子大师
cd6 分子：该基因编码一种在 t 淋巴细胞和其他一些免疫细胞外膜上发现的蛋白质。编码的蛋白质包含三个清道夫受体富含半胱氨酸 (SRCR) 结构域和一个活化白细胞粘附分子的结合位点。
华美生物
https://www.cusabio.cn › target
CD6- 信号通路|蛋白抗体-华美生物
cd6是一种关键的1型跨膜糖蛋白，其细胞外部分包含三个富含半胱氨酸的清道夫受体结构域，高度糖基化，并与免疫球蛋白超家族分子cd166（alcam）作为其主要配体相互作用。
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