Herein, a CD7-specific immuno-nanotoxin based on anti-CD7 nanobody-modified polymersome-mertansine nanoconjugates (aCD7-Ps-DM1) was engineered to enable effective and targeted chemotherapy of orthotopic T-ALL in vivo. aCD7-Ps-DM1 with regulable aCD7 density showed no DM1 leakage while rapid DM1 release under reducing conditions.

The VHH chain of the human CD7 nano antibody disclosed by the invention or the human CD7 nano antibody is coded by the DNA molecule. The invention also discloses a host cell, which can express...

The invention discloses the VHH chain of a kind of people's CD7 nano antibody, including framework region FR and complementary determining region CDR, the aminoacid sequence of FR1～FR4 that...

Provided is a nanometer antibody for human CD7 molecule and an encoding DNA sequence thereof. The nanometer antibody can be efficiently expressed in Escherichia coli, and can be used for...

acd7-ps-dm1 免疫纳米毒素有效靶向 cd7 阳性 ccrf-cem t-all 细胞，其抗 all 活性比非靶向 ps-dm1 和 cd7 阴性 b- 细胞高 5 倍和 13 倍以上。 分别是所有细胞系。 在原位 CCRF-CEM T-ALL 荷瘤小鼠中，重复（多次）给药 aCD7-Ps-DM1 持续抑制白血病的进展和骨髓、血液和器官的浸润 ...

The nano antibody can be efficiently expressed inside escherichia coli by the nano antibody gene sequence and the host cell disclosed by the invention, and can be applied to research and development of a CD7 molecule detection reagent.

2011年11月30日 · Single chain variable fragment CD7 antibody conjugated PLGA/HDAC inhibitor immuno-nanoparticles: developing human T cell-specific nano-technology for delivery of therapeutic drugs targeting latent HIV

CD7，又称GP40，是一种膜表达蛋白,属于免疫球蛋白超级家族，存在于胸腺细胞和成熟的T细胞中。在早期淋巴细胞发育过程中，在T细胞相互作用和T细胞/ B细胞相互作用中起重要作用。 （数据来源 The Human Protein Atlas） CD7结构：

PA3-17 is a CAR-T cell injection based on CD7 nano antibodies, by blocking the expression of CD7 molecule on the surface of T cells through anti-CD7 protein expression blocker (PEBL) .

2022年8月22日 · CD7 (T细胞抗原7，又称作GP40，TP41，LEU-9)是一种单链跨膜糖蛋白，40kDa，，包含240个氨基酸残基，属于免疫球蛋白超家族成员。 CD7通常表达于85%的外周血T细胞和NK细胞及其前体细胞，是一种辅助T细胞活化和与其他免疫亚群细胞相互作用的共刺激受体蛋白。 某些正常T细胞的CD7不表达，其对T细胞的发育、成熟和功能并无显著影响。 CD7基因位于人17号染色体上，其DNA长度为3.0 kb，其转录产生的mRNA包含4个外显子，分别为类 …