CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin.

2024年12月24日 · CD72 (CD72 Molecule) is a Protein Coding gene. Diseases associated with CD72 include Systemic Lupus Erythematosus and Leukemia, Chronic Lymphocytic. Among its related pathways are Nervous system development and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and …

2024年4月25日 · 本文将概述CD72蛋白的基本特性、功能，并探讨其潜在的应用前景。 一、CD72蛋白的基本特性. CD72蛋白属于CD分子家族，是一种跨膜糖蛋白。 它在免疫细胞的细胞膜上表达，通过与其配体的相互作用，参与细胞信号转导和细胞间通讯。 CD72蛋白的结构独特，包括一个胞外域、一个跨膜区和一个胞内域，这种结构使得它能够与其他细胞或分子进行相互作用，从而调节细胞的生物学行为。 二、CD72蛋白的生物学功能. 免疫调节：CD72蛋白在B细胞和T …

CD72 is a B cell coreceptor that has been shown to interact with CD100, a semaphorin, and to enhance BCR signaling. Discussion: CD72 ligation induces a variety of early signaling events such as activation of the Src kinases Blk and Lyn and the non-src kinase Btk leading to activation of the mitogen-activated protein (MAP) kinases, events ...

CD72 is a transmembrane receptor expressed as a homodimer that plays a negative role in B cell activation by recruiting SHP1 and influencing the responsiveness and survival of B cells. AI generated definition based on: Kelley and Firestein's Textbook of …

2024年6月1日 · CD72 is an inhibitory B cell co-receptor that down-regulates BCR signaling, and prevents the development of SLE. We previously showed that CD72 recognizes the RNA-containing self-antigen Sm/RNP, a target of SLE-specific autoantibodies, and induces B cell tolerance to Sm/RNP by specifically inhibiting B cell response to this self-antigen.

1998年9月10日 · Results: We identified the B-cell transmembrane protein CD72 as a new SHP-1 binding protein and as an in vivo substrate of SHP-1 in B cells. We also defined the binding sites for SHP-1 and the adaptor protein Grb2 on CD72.

2023年11月18日 · This study aimed to determine whether CD72 is associated with the prognosis and immune infiltration of KIRC, providing an essential molecular basis for the early non-invasive diagnosis and immunotherapy of KIRC.

CD72, a type II transmembrane protein that is primarily expressed in B cells, was found to play an immunomodulatory role in the immune system and was associated with mortality in patients with sepsis. However, whether CD72 affects the pathogenesis of sepsis by influencing the immune response remains unclear.

CD72 蛋白在协调 B 细胞增殖和分化、形成具有二硫键的同二聚体以及与 CD5 相互作用方面发挥着关键作用。 它与 PTPN6/SHP-1 进行酪氨酸磷酸化相互作用，表明它通过基于磷酸化的调节机制来调节细胞反应。 这强调了 CD72 在 B 细胞功能和信号传导动态景观中的多方面作用。 FITC-Labeled CD72 Protein, Human (HEK293, Fc) 是重组的 FITC 标记的 CD72 蛋白，由 HEK293 表达，带有 Fc 标签。 FITC-Labeled CD72 Protein, Human (HEK293, Fc) 全长 243 个氨基酸，分 …