CD72, a coreceptor with both positive and negative effects on B ...
Coreceptors on B cells can modulate the thresholds for signaling through the BCR for growth and differentiation. CD72 is a B cell coreceptor that has been shown to interact with CD100, a …
CD72 Gene - GeneCards | CD72 Protein | CD72 Antibody
Dec 24, 2024 · CD72 (CD72 Molecule) is a Protein Coding gene. Diseases associated with CD72 include Systemic Lupus Erythematosus and Leukemia, Chronic Lymphocytic . Among its …
CD72 Is a Pan-Tumor Antigen Associated with Childhood Acute …
Nov 15, 2022 · Based on the findings described below, we here propose CD72 as a novel and robust pan-acute leukemia TAA. Even though CD72 is known to be expressed by B-lineage …
Surface proteomics reveals CD72 as a target for in vitro-evolved ...
CD72, also known as lyb-2 in murine biology, is a single-pass Type-II membrane protein with an extracellular C-type lectin domain and cytoplasmic ITIM motifs. The ITIM motifs on CD72, …
A regulatory role for CD72 expression on B cells and increased …
Apr 19, 2020 · Here, we examined the expression of CD72 on B cells, and for the first time, the level of the soluble form of CD72 in pSS patients. Our findings suggest that expression of …
CD72, a new immune checkpoint molecule, is a novel prognostic …
Nov 18, 2023 · Our study suggests that CD72 is associated with tumor immunity and may be a biomarker relevant to the diagnosis and prognosis of KIRC patients.
CD72 - an overview | ScienceDirect Topics
CD72 is a transmembrane receptor expressed as a homodimer that plays a negative role in B cell activation by recruiting SHP1 and influencing the responsiveness and survival of B cells. AI …
Positive and negative roles of CD72 in B cell function - PubMed
CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV …
The B-cell transmembrane protein CD72 binds to and is an
Results: We identified the B-cell transmembrane protein CD72 as a new SHP-1 binding protein and as an in vivo substrate of SHP-1 in B cells. We also defined the binding sites for SHP-1 …
CD72 is an inhibitory pattern recognition receptor that recognizes ...
Jun 1, 2024 · CD72 recognizes ribosomes, and inhibits ribosme-induced B cell activation. CD72 suppresses production of anti-ribosome autoantibody. CD72 plays a crucial role in B cell …
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