2020年7月1日 · CD96 is a promising candidate for immunotherapy. However, its role and importance in glioma remains unknown. We thus aimed to genetically and clinically characterize CD96 expression in gliomas.

CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8 + T cell-dependent manner.

In the analysis of CD96 and immune metagenes, we found that CD96 expression was correlated with T-cell- and macrophage-related, but not B cell-related immune responses. Our results show that CD96 is a negative prognostic marker in glioma and plays an …

Blocking CD96-CD155 interaction or TGF-β1 restores NK cell immunity against tumors by reversing NK cell exhaustion, suggesting a possible therapeutic role of CD96 in fighting liver cancer.

Here, we demonstrate that CD96 has co-stimulatory function on CD8 + T cells. Crosslinking of CD96 on human or mouse CD8 + T cells induced activation, effector cytokine production, and proliferation. CD96 was found to transduce its activating signal through the MEK-ERK pathway.

CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8 + T cell–dependent manner.

2024年12月24日 · CD96 (CD96 Molecule) is a Protein Coding gene. Diseases associated with CD96 include C Syndrome and Developmental And Epileptic Encephalopathy 29. Among its related pathways are Innate Immune System and Class I …

CD96 represents a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD96 is expressed mainly by cells of hematopoietic origin, in particular on T and NK cells. Upon interaction with CD155 present on target cells, CD96 ...

2019年4月1日 · CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor …

2021年2月18日 · CD96, a novel immune checkpoint expressed on T cells and natural killer (NK) cells, is essential for regulating immune functions. However, how CD96 correlating with immune infiltration and patient prognosis in pan-cancer remains unclear.