2020年7月30日 · Conventional dendritic cells (cDCs) comprise two subsets, type 1 (cDC1) and type 2 (cDC2). Plasmacytoid DCs (pDCs) are specialized for type I interferon (IFN) secretion. Every subset expresses a...

cDC2是存在于人体不同组织和器官中主要的DC群体，它们表达一系列TLRs，能够对从核苷酸到多糖的各种危险信号作出反应。 与其他稳态DC亚群相比，它们还表达了高水平的NLRPs和其他炎症相关信号分子，表明它们具有感知不同危险信号的功能。

cDC2细胞具有一般DC家族的功能，通过MHC II类抗原呈递以及共刺激活化Naive CD4 + T细胞。 cDC1细胞专门用于交叉提呈，或在MHC I类上提呈外源抗原，以诱导Naive CD8 + T细胞分化并激活[ 7 ]。

2019年11月19日 · In Cell, Rudensky and colleagues describe two distinct subsets of cDC2s in mice and humans. Through the use of Tbx21RFP-Cre reporter mice and single-cell RNA sequencing, the authors identify a...

cdc 基因 （cell division cycle gene，细胞分裂周期基因）是一类产物表达具细胞周期依赖性或直接参与细胞周期调控的基因，主要包括cyclin基因、Cdk基因、CKI基因等。 此外，与DNA复制相关的 DNA聚合酶 、 DNA连接酶 基因也属于cdc基因。 酵母 中这些与细胞分裂和 细胞周期调控 有关的 基因，被称为cdc (cell division cycle)基因。 人们根据cdc基因被发现的先后顺序对这些基因进行了命名，如cdc2、cdc25、cdc28等。

2024年2月13日 · Our results showed that cDC2A versus cDC2B fate specification starts in the bone marrow and suggest that cDC2 subsets are ontogenetically determined lineages, rather than cell states imposed by...

Cell cycle control by cdks and cdk inhibitors: cdc2 versus CDK2 and CDK4/6. Interactions between cdc2 and cell cycle regulatory molecules/transcription factors pRb and E2F. If cdc2 is a pluripotent CDK, what are the fundamental mechanisms responsible for the multiple functions of cdc2 described above?

Several regions in Cdc2 are involved in binding cyclins A and B. Phosphorylation of cyclin/Cdk complexes ensures that the kinase activity peaks at a specific time in the cell cycle. Phosphorylation of Thr161 in Cdc2 is required for strong cyclin binding and kinase activity in vitro; its dephosphorylation is necessary for cells to exit mitosis.

Conventional dendritic cells (cDCs) comprise two subsets, type 1 (cDC1) and type 2 (cDC2). Plasmacytoid DCs (pDCs) are specialized for type I interferon (IFN) secretion. Every subset expresses a specific profile of cell surface markers and transcription factors (TFs).

Accumulating evidence shows that cdc2 not only promotes G (2)-M transition but is also capable of regulating G (1) progress and G (1)-S transition via association with multiple interphase cyclins; cdc2 activity can be inhibited by p21 and p27, two traditional G (1) CDK inhibitors.