M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

Cdc25A activates cyclin D-CDK4 complex and cyclin E-CDK2 complex, which phosphorylate Rb and dissociate Rb from complex with E2F1, releasing inhibition on E2F1, whose activity is …

Overexpression of Cdc25A promotes tumorigenesis, and is frequently observed in various types of cancer. Here we briefly summarize current understanding of the role of Cdc25A in cell …

2024年12月24日 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin …

2016年4月21日 · We report here on a genome-wide CRISPR-Cas9 screen that identified CDC25A as a major determinant of sensitivity to ATR inhibition. CDC25A-deficient cells resist high …

Studies found that CDC25A, together with CDC25B and CDC25C, generates a cellular phosphatase pool required for full activation of cyclinB-Cdk1. CDC25A binds to cyclinB-Cdk1 …

2021年8月6日 · Here we describe a novel ubiquitin/proteasome-mediated pathway negatively regulating CDC25A stability, dependent on its phosphorylation by the serine/threonine kinase …

2025年1月4日 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent …

2025年2月8日 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent …

Mammals contain at least three cdc25+ homologues called cdc25A, cdc25B and cdc25C. In this study we investigate the biological function of cdc25A. Although very potent in rescuing the …