CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. [5] [6] [7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins. [8] CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell ...

2024年12月24日 · CDC34 (Cell Division Cycle 34, Ubiqiutin Conjugating Enzyme) is a Protein Coding gene. Diseases associated with CDC34 include Three M Syndrome 1. Among its related pathways are Class I MHC mediated antigen processing and presentation and …

2019年7月24日 · Cdc34 is an E2 that plays a key role in regulating cell cycle progression and requires unique structural elements to function. The molecular basis by which Cdc34 engages its E1 and the...

2025年2月9日 · Cdc34 is a functional target of let-7 and that let-7 induces down-regulation of Cdc34, stabilization of the Wee1 kinase, and an increased fraction of cells in G(2)/M in primary fibroblasts. Observational study of gene-disease association.

Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues. 该基因编码的蛋白质是泛素结合酶家族的成员。 泛素结合酶催化泛素与其他蛋白质的共价连接。 这种蛋白质是大型多蛋白复合物的一部分，它是泛素介导的细胞周期 G1 调节因子降解和 DNA 复制启动所必需的。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a member of the ubiquitin-conjugating Enzyme family.

Our results showed that CDC34 was overexpressed and inversely associated with clinical outcome of the patients, and promoted NSCLC cell proliferation in vitro and in vivo. CDC34 stabilized EGFR by binding with it at Y1045 to dissociate c-Cbl and thus prevented subsequent ubiquitination and degradation.

2019年11月9日 · 研究者Katelyn Williams表示，我们重点对Cdc34进行研究是因为其具有一定的临床相关性，Cdc34是很多生物学过程和癌症异常功能的关键调节子；同时Cdc34 ...

CDC34 competes with c-Cbl to bind Y1045 to inhibit polyubiquitination and degradation of EGFR. In EGFR-L858R and EGFR-T790M/Del (exon 19)-driven lung tumor growth in mouse models, knockdown of CDC34 significantly inhibits tumor formation.

Immunohistochemistry and cellular fractionation reveals a heterogeneous CDC34 expression pattern including cells containing primarily cytoplasmic or nuclear protein. Thus, a feature of pediatric T-cell ALL is posttranscriptional up-regulation and heterogeneous localization of the human CDC34 UBC.

2017年6月13日 · Silencing of TbCDC34 in BSF cells resulted in a block in cytokinesis and caused rapid clearance of parasites from infected mice. We also show that TbCDC34 is able to conjugate ubiquitin in vitro and in vivo, and that its activity is necessary …