2024年12月24日 · CDC45 (Cell Division Cycle 45) is a Protein Coding gene. Diseases associated with CDC45 include Meier-Gorlin Syndrome 7 and Meier-Gorlin Syndrome 1. Among its related pathways are Activation of the pre-replicative complex and Mitotic G1 phase and G1/S transition.

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is ...

2016年5月18日 · Here we report the 2.1-Å crystal structure of human Cdc45, which confirms its evolutionary link with the bacterial RecJ nuclease and reveals several unexpected features that underpin its function...

Cdc45 是高度保守的多蛋白复合物的成员，包括 Cdc6/Cdc18、微型染色体维持蛋白 (MCM) 和 DNA 聚合酶，这对于真核生物中 DNA 复制的早期步骤很重要。 这种蛋白质已被证明与 MCM7 和 DNA 聚合酶 α 相互作用。

2024年7月9日 · CDC45 encodes a DNA replication initiation factor that is a subunit of the CMG DNA helicase complex involved in DNA replication initiation and double-strand break repair via break-induced replication. CDC45/YLR103C is located on the right arm of chromosome XII between strong replication origin ARS1212.5 and uncharacterized gene LCL2.

CDC45 is the core component of CMG (CDC45‐MCMs‐GINS) complex that plays important role in the initial step of DNA replication in eukaryotic cells. The expression level of cdc45 is under the critical control for the accurate cell cycle progression.

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is ...

2024年10月6日 · Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha.

2022年6月2日 · Loss-of-function of cdc45 has been demonstrated to inhibit cell proliferation and leads to cell death due to the inhibition of DNA replication and G1-phase arrest. An increasing of CDC45 inhibits cell proliferation as well. Nevertheless, a systematic analysis of the effect of high dose of CDC45 on cell physiology and behaviors is unclear.

The CDC45 gene of Saccharomyces cerevisiae was isolated by complementation of the cold-sensitive cdc45-1 mutant and shown to be essential for cell viability.