Cdc48: a power machine in protein degradation - ScienceDirect
2011年10月1日 · Cdc48 is an essential, highly prominent ATP driven machine in eukaryotic cells. Physiological function of Cdc48 has been found in a multitude of cellular processes, for …
Visualization of the Cdc48 AAA+ ATPase protein unfolding …
2024年8月29日 · Here, we report an ensemble of native structures of Cdc48 affinity purified from budding yeast lysate in complex with the adaptor Shp1 in the act of unfolding substrate. Our …
Science：从结构上揭示细胞利用Cdc48解折叠蛋白机制 - 华人研究 …
多年来，科学家们已知道Cdc48中的单点突变经过一系列级联反应后导致严重的疾病，包括肌萎缩侧索硬化症（amyotrophic lateral sclerosis, ALS）和腓骨肌萎缩症2Y型（Charcot-Marie …
哈佛等解析VCP/p97/CDC48参与底物去折叠功能的结构 - 脉脉
2019年8月13日 · Cdc48/p97的基因突变和多种疾病相关，包括多系统蛋白病（multisystem proteinopathy），家族性肌萎缩侧索硬化症（familial amyotrophic lateral sclerosis），腓骨肌 …
Cdc48: A Swiss Army Knife of Cell Biology - PMC - PubMed …
Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its …
Structure of the Cdc48 segregase in the act of unfolding an
2019年6月27日 · Cdc48 (human homolog known as p97/VCP) is an abundant and essential AAA+ ATPase (adenosine triphosphatase) that separates protein substrates from complexes, …
Molecular Mechanism of Substrate Processing by the Cdc48
2017年5月4日 · Cdc48 consists of an N-terminal domain that binds UN and two stacked hexameric ATPase rings (D1 and D2) surrounding a central pore. Here, we use purified …
Structure of the Cdc48 segregase in the act of unfolding an …
2019年8月2日 · The cellular machine Cdc48 functions in multiple biological pathways by segregating its protein substrates from a variety of stable environments such as organelles or …
Cdc48: a power machine in protein degradation - Cell Press
2011年7月8日 · Cdc48 is an essential, highly prominent ATP driven machine in eukaryotic cells. Physiological function of Cdc48 has been found in a multitude of cellular processes, for …
The Cdc48 machine in endoplasmic reticulum associated protein ...
2012年1月1日 · The AAA-type ATPase Cdc48 (named p97/VCP in mammals) is a molecular machine in all eukaryotic cells that transforms ATP hydrolysis into mechanic power to unfold …
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