2024年12月24日 · CDH11 (Cadherin 11) is a Protein Coding gene. Diseases associated with CDH11 include Elsahy-Waters Syndrome and Teebi Hypertelorism Syndrome 2. Among its related pathways are Regulation of CDH11 Expression and Function and Cell junction organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene. [5][6] This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion.

2023年12月1日 · CDH11 is a type II classical cadherin, initially discovered in murine osteoblasts, hence referred to as Osteoblast Cadherin (OB -cadherin). The cdh11 gene is situated on 16q22.1 and spans an approximately 3.8 kb complementary DNA (cDNA), encompassing 16 exons that encode a polypeptide of 796 amino acids.

2011年12月5日 · CDH11 was broadly expressed in human normal adult and fetal tissues, while its silencing and promoter CpG methylation were frequently detected in tumor cell lines, but not in immortalized normal...

该基因编码来自钙粘蛋白超家族的 II 型经典钙粘蛋白，即介导钙依赖性细胞粘附的整合膜蛋白。 成熟的钙粘蛋白由一个大的 N 末端胞外结构域、一个单一的跨膜结构域和一个小的、高度保守的 C 末端胞质结构域组成。 II 型 (非典型) 钙粘蛋白是根据它们缺乏 I 型钙粘蛋白特有的 HAV 细胞粘附识别序列来定义的。 这种特殊钙粘蛋白在成骨细胞系中的表达及其在分化过程中的上调表明在骨骼发育和维持中具有特定功能。 [RefSeq 提供，2008 年 7 月]

2011年6月21日 · Cadherin 11 (CDH11), which is selectively expressed on fibroblasts, has been implicated as an important mediator of inflammation: anti-CDH11 monoclonal antibodies reduced inflammation...

CDH11 often leads to promoter methylation inactivation, which can induce cancer cell apoptosis, suppress cell motility and invasion, and can inhibit cancer through Wnt/β-catenin, AKT/Rho A and NF-κB signaling pathways. This review focused on the current knowledge of CDH11, including its function and mechanism in different diseases.

CDH11 is an inductor of metastatic signaling, and biomarker of poor prognosis in metastatic breast cells (MBCs). Exposure to anti-CDH11 antibody suppresses metastasis, reduces CDH11, fibronectin and beta-catenin expression, and abrogate …

2015年5月1日 · CDH11 mediated AJ formation promotes MSC differentiation into SMC. Accumulating evidence suggests that the mechanical and biochemical signals originating from cell–cell adhesion are critical for stem cell lineage specification.

2022年2月1日 · Cadherins, such as CDH11, are cell surface glycoproteins that mediate Ca (2+)-dependent cell-cell adhesion.