抗肿瘤药物靶标：周期蛋白依赖性激酶4/6 (CDK4/6) - 知乎
被激活的cyclin D-CDK4/6复合物磷酸化 视网膜母细胞瘤相关蛋白 (retinoblastoma-associated protein, Rb),进而使转录抑制复合物Rb-E2F解聚，释放E2F转录因子。 接着，游离的E2F激活细 …
What Are CDK4/6 Inhibitors? - Breastcancer.org
CDK4/6 inhibitors are a class of medicines used to treat certain types of metastatic breast cancer, which is cancer that has spread to other parts of the body.
List of CDK 4/6 inhibitors + Uses, Types & Side Effects - Drugs.com
2023年4月14日 · CDK4/6 inhibitors are a class of drugs that target particular enzymes, called CDK4 and CDK6. CDK stands for cyclin-dependent kinase, and it is an enzyme that is …
CDK4/6 Inhibitors - Susan G. Komen®
2025年2月27日 · CDK4/6 inhibitors are pills that are used in combination with hormone therapy (also called endocrine therapy) to treat some hormone receptor-positive breast cancers. Used …
A Review of CDK4/6 Inhibitors - U.S. Pharmacist
2020年5月15日 · Three CDK4/6 inhibitors (palbociclib, ribociclib, and abemaciclib) have been approved for patients with hormone receptor–positive, human epidermal growth factor receptor …
Understanding the Best Practices Associated With CDK4/6 Therapy …
2025年3月10日 · At the 42nd Annual Miami Breast Cancer Conference, Dr. Sara M. Tolaney sat down for an interview with CURE to discuss the efficacy and breast practices associated with …
CDK4 and CDK6 kinases: From basic science to cancer therapy
2022年1月14日 · Cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) and their activating partners, D-type cyclins, link the extracellular environment with the core cell cycle machinery. …
CDK4/6 Inhibitors: Game Changers in the Management of …
The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors palbociclib, ribociclib, and abemaciclib are rapidly transforming the care of patients with hormone receptor (HR)-positive, human …
CDK 4/6 Inhibitors in Breast Cancer: Current Controversies and …
Palbociclib, ribociclib, and abemaciclib are all orally active, highly selective reversible inhibitors of CDK4 and CDK6 approved by the Food and Drug Administration (FDA) for hormone receptor …
CDK 4/6 Inhibitors: Mechanisms, Applications, and Insights
3 天之前 · Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a critical class of targeted therapies, particularly in hormone receptor-positive breast cancer. These drugs disrupt specific …