CDK1的激活是通过与细胞周期素B1结合或者被CDK活化激酶(CDK activating kinase,CAK)磷酸化来实现的，它既与G1期向S期的转变密切相关，也能通过一系列复杂的相互作用推动细胞从间期的G2期进入分裂期。

2023年6月13日 · The cysteine-rich CXC domain of Lin-54 DREAM MuvB core complex component (LIN54) is a novel DNA-binding domain that binds to the CDK1 promoter in a sequence-specific manner 53. Besides directly...

2010年8月23日 · The mitochondrial kinase activity of cyclin B1/Cdk1 was found to specifically phosphorylate p53 at Ser-315 residue, leading to enhanced mitochondrial ATP production and reduced mitochondrial apoptosis. The improved mitochondrial function can be blocked by transfection of mutant p53 Ser-315-Ala, or by siRNA knockdown of cyclin B1 and Cdk1 genes.

In the study presented here, we investigated the effects of CCNB1/cdk1 knock down by siRNA and analyzed the consequences of RO-3306 mediated cdk1 inhibition as a function of variable expression of MYCN and p53 in preclinical models of embryonal tumors including neuroblastoma, medulloblastoma and rhabdomyosarcoma.

2023年10月28日 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is modulated by its...

2015年3月10日 · We found that inhibiting cyclin-dependent kinase 1 (CDK1) leads to activation of the DNA damage response, nuclear p53 stabilization, activation of a subset of p53 target genes including NOXA, and negative regulation of the anti-apoptotic protein MCL1 in human and mouse ESCs, but not differentiated cells.

Here, we provide a comprehensive catalogue of the CDK1 upstream regulators and substrates, describing how this kinase is implicated in the control of key ‘cell cycle-unrelated biological...

2015年6月20日 · Apoptosis induced by cdk1 inhibition was dependent on caspase activation and was concomitant with upregulation of transcriptional targets of TP53. Our results confirm an essential role for the cdk1/CCNB1 complex in tumor cell survival.

CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all eukaryotes. Here we report the crystal structures of complexes of CDK1–Cks1 and …

2014年12月29日 · We show that ATF2 (at Thr-69/Thr-71) and ATF7 (at Thr-51/Thr-53) are phosphorylated by cyclin-dependent kinase 1 (Cdk1) in M phase. Notably, we find that, similar to knockdown of ATF7, the expression of a mitotically nonphosphorylatable ATF7 mutant protein inhibits entry of cells into M phase.