2025年3月7日 · Cyclin-dependent kinase 1 (CDK1) is the pivotal kinase responsible for initiating cell division. Its activation is dependent on binding to regulatory cyclins, such as CCNB1....

19532-1-AP targets CDK1-Specific in WB, IHC, IF/ICC, FC (Intra), IP, ELISA applications and shows reactivity with human, mouse, rat, monkey samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

6 天之前 · In late G2 phase, the CDK1/Cyclin B1 complex translocates to the nucleus, where it phosphorylates the S217 residue of CARM1. ... C IP using anti-CARM1 antibody in cells co-transfected with HA-CDK1 ...

... prepositioning CDK1 to chromosome ends where it executes the function. The physical interaction between cGAS and CDK1 was examined by co-IP. The results showed that both endogenous and...

2025年2月18日 · In this study, we focused on understanding the interplay between CDK1, USP37, and SND1 in CRC, proposing a new regulatory mechanism whereby CDK1 phosphorylates USP37, enhancing its deubiquitinating activity on SND1. Our research confirmed the direct binding between USP37 and SND1 and further unveiled the pivotal role of …

2008年4月14日 · Here, we demonstrate that cyclin-dependent kinase 1 (CDK1) specifically phosphorylates FOXO1 at serine 249 (S249) in vitro and in vivo. Coimmunoprecipitation assays demonstrate that both...

Wang et al. find that cyclin B1/Cdk1 localizes to the mitochondrial matrix and phosphorylates complex I to boost mitochondrial respiration and ATP generation during G2/M. Mitochondrial cyclin B1/Cdk1 thus enables cell-cycle regulation of mitochondrial respiration to serve the increased cellular energy demand of the G2/M transition.

2022年2月4日 · CDK1 phosphorylates BLM to promote BLM-PLK1 association and also regulates TOPBP1-PLK1 binding, possibly by phosphorylating TOPBP1. By interacting with BLM and PLK1 and possibly through its ability to form nuclear condensates, TOPBP1 creates a subcellular environment that increases the efficiency of BLM phosphorylation.

A) Immunoprecipitation (IP) coupled with immunoblotting (IB) assays using the indicated antibodies testing the effect of CDK1 on ACSL4 phosphorylation. B) Mass spectrometry identifying the...

Using ReactomePA ( Yu and He, 2016), we identified different cell-cycle regulators, including cyclin-dependent kinase 1 (CDK1), as potential binding partners for DUX4, providing a rationale for...