Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial …

Ckd5是作为一种多功能激酶，其主要功能是参与神经细胞迁移、轴突导向、突触发生与传递，近年来研究发现，CDK5在多种组织中表达，它可以通过磷酸化不同的调节底物发挥多种生物学作 …

2024年12月24日 · CDK5 (Cyclin Dependent Kinase 5) is a Protein Coding gene. Diseases associated with CDK5 include Lissencephaly 7 With Cerebellar Hypoplasia and …

2024年9月4日 · CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.

The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The …

2001年10月1日 · Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system.

2025年1月21日 · This review explores the structure and biological functions of CDK5, highlighting its regulatory roles in disease development through the phosphorylation of diverse substrate …

2019年11月6日 · Treatment with the CDK5 inhibitor roscovitine sensitizes cells to heat-induced apoptosis and its phosphorylation, which results in prevention of the apoptotic protein …

2011年12月20日 · Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been …

2024年11月15日 · 最新研究证明，CDK5的抑制剂如CDK5抑制肽（CDK5 inhibitory peptide，CIP）、萝卜硫素（sulforaphene，SF）能够破坏CDK5和p25之间的相互作用，抑 …