CE3F4 | Epac1 Antagonist | MCE - MCE-生物活性分子大师
CE3F4 是 Epac1 的选择性拮抗剂，对 Epac1 和 Epac2 (B) 的 IC 50 分别为 10.7 μM 和 66 μM。CE3F4 对 Epac1 的活性高于 (S) -立体异构体 ( (S) -CE3F4，IC 50 ，56 μM)，但低于 (R) …
Membranes prime the RapGEF EPAC1 to transduce cAMP signaling
2023年7月12日 · Examination of the cell-active chemical CE3F4 in this framework further reveals that it targets only fully activated EPAC1. Together, our findings reformulate previous concepts …
Identification of a Tetrahydroquinoline Analog as a Pharmacological ...
2012年12月28日 · Here, we have developed a functional fluorescence-based high-throughput assay with a Z′ value around 0.7 for screening Epac-specific antagonists. We identified an …
The (R)-enantiomer of CE3F4 is a preferential inhibitor of human ...
2013年10月25日 · In this study, we report that (R)-CE3F4 is a more potent cAMP antagonist than racemic CE3F4 and (S)-CE3F4, inhibiting the GEF activity of Epac1 with 10-times more …
CE3F4 | Epac1 Antagonist - MedChemExpress
CE3F4 reduces the exchange activity of Epac1 induced by 007, with IC 50 of 23 ± 3 μM. CE3F4 (40 μM) specifically inhibits Epac1 guanine nucleotide exchange activity without interference …
Ca2+ influx through L-type Ca2+ channels and Ca2+-induced …
2016年1月1日 · To corroborate our findings from the cell-based ELISA, we examined the effect of pre-treatment with the Epac1-selective antagonist CE3F4 on ERK activation using EKAR. …
CE3F4 | cAMP | TargetMol
在活的培养HEK293细胞中，CE3F4 (20 μM)能抑制Epac诱导的Rap1激活[2]，且显著抑制INS-1细胞中葡萄糖刺激的ERK活化后期[3]。 CE3F4 (40 μM)专一性抑制Epac1的鸟苷酸交换活性，而 …
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【CE3F4】CE3F4 CAS号:143703-25-7【结构式 性质 活性】-化源网
CE3F4 (20μM)显着抑制INS-1细胞中葡萄糖刺激的ERK活化晚期 [3]。 为了确定Epac1交换活性，将200nM预装有bGDP的纯化GST-Rap1A在22℃下在交换缓冲液（50mM Tris-HCl（pH …
(R)-CE3F4 | Ra 抑制剂 | MCE - MCE-生物活性分子大师
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC 50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC …
美国GlpBio - CE3F4 | Ras-like GTPases | Cas# 143703-25-7
CE3F4 is a selective antagonist of Epac1, with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively. CE3F4 is more active on Epac1 than (S)-stereoisomer ((S)-CE3F4, …
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