2010年11月10日 · Using in vivo electrophysiological, optogenetic and pharmacological approaches in mice, we show that neuronal activity in the lateral subdivision of the central amygdala (CEl) is required for...

2021年7月6日 · Our findings identify CEA inhibitory microcircuits that act as critical elements within the brain networks mediating fear extinction. The survival of animals depends on their ability to...

2020年1月22日 · Consistent with CRF being and important modulatory system for regulating fear, CRF signaling enhances synaptic strength in the CeA and serves as a gain control for the formation of fear...

The historically understood role of the central amygdala (CeA) in fear learning is to serve as a passive output station for processing and plasticity that occurs elsewhere in the brain. However, recent research has suggested that the CeA may play a more dynamic role in fear learning.

2021年11月2日 · 焦虑障碍是一类以机体对外源性和内源性刺激表现出过度恐惧、焦虑或回避行为为特征的精神疾病（包括广泛性焦虑症、社交焦虑症、创伤后应激障碍、分离焦虑症、恐慌症等） 。 我国2019年精神疾病流行病学调查结果显示，焦虑障碍已成为我国发病率最高的精神疾病，12个月患病率为5.0%，终生患病率高达7.6% 。 值得注意的是，当前全球新型冠状病毒肺炎疫情肆虐，更是加剧了人们的焦虑、恐惧、紧张等普遍性精神健康问题。 一项大型研究发现，在 …

2010年8月26日 · The central nucleus of the amygdala (CeA) serves as a major output of this structure and plays a critical role in the expression of conditioned fear. By combining cell- and tissue-specific pharmacogenetic inhibition with functional magnetic resonance imaging (fMRI), we identified circuits downstream of CeA that control fear expression in mice.

The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of fear is unclear.

焦虑（anxiety）是一种先天或后天习得的对将来的、未知的危险/威胁信号的情绪反应；而恐惧（fear）是对当前的、已知的危险/威胁信号的情绪反应。当中性刺激（如声音）反复地同强烈的厌恶刺激（如电击）相联结时，人和动物会迅速地对原来的中性刺激形成 ...

2018年5月15日 · The CEA mediates motor and autonomic responses to fear and stress by targeting nuclei in the midbrain and in the hypothalamus [(19), for a review, see Tovote et al. (3)]. In addition, surrounding the BLA, there are several small clusters of GABAergic neurons, the so-called intercalated cell masses (ITCs) (20) .

2013年1月27日 · We found that fear conditioning in mice induced robust plasticity of excitatory synapses onto inhibitory neurons in the lateral subdivision of the CeA (CeL). This experience-dependent...